Scopus
YÖKSİS Eşleşti
Effect of cigarette smoking on serum methylarginine and α-klotho levels
Nutrition, Metabolism and Cardiovascular Diseases · Mart 2023
YÖKSİS Kayıtları
Effect of cigarette smoking on serum methylarginine and α-klotho levels
Elsevier BV · 2023 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Effect of cigarette smoking on serum methylarginine and alfa-klotho levels
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES · 2023 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiNutrition, Metabolism and Cardiovascular Diseases
Yayın TarihiMart 2023
Cilt / Sayfa33 · 602-609
Scopus ID2-s2.0-85148479624
Özet
Background and aims: Smoking causes many diseases such as cardiovascular, lung diseases, stroke and premature aging. However, the role of smoking in the pathogenesis of these diseases is unclear. Increasing evidence suggests that methylarginine pathway metabolites and α-klotho may be strong markers for pathologies such as premature aging, endothelial dysfunction, and oxidant damage. Therefore, the study aimed to measure the serum levels of arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), N-monomethyl-L-arginine (L-NMMA), and α-klotho levels in smokers. Methods and results: This case-control analytical study included 65 smokers and 71 non-smokers. Sociodemographic characteristics, routine biochemistry parameters, Framingham risk scores and Fagerström Nicotine Dependence Test (FTND) were recorded. Serum methylarginine and α-klotho levels were analyzed by tandem mass spectrometry and enzyme-linked immunosorbent assay (ELISA), respectively. Serum ADMA (p < 0.001), L-NMMA (p = 0.024), SDMA (p < 0.001) levels of smokers were higher than non-smokers, and serum α-klotho (p < 0.001) and arginine levels (p < 0.001) were lower. There was a positive correlation between serum ADMA levels with FNDT, age and pack/year in smokers, while there was a negative correlation between klotho levels and age. A positive correlation was found between serum ADMA levels, Framingham risk score and age in non-smokers. Conclusion: Smoking is related to premature aging and is a strong risk factor for various diseases such as cardiovascular, inflammatory, and renal diseases. Elevated serum methylarginine and decreased serum klotho levels were found in smokers. Therefore, our findings suggest that smoking may be involved in the pathogenesis of these diseases by affecting α-klotho and methylarginine-related pathways.
Yazarlar (5)
1
Mustafa Onmaz
2
Nur Demirbaş
ORCID: 0000-0002-4038-9386
3
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
4
Ruhuşen Kutlu
5
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
ADMA
Aging
Arginine
Methylarginine
Smoking
α-klotho
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
7
Atıf
5
Yazar
6
Anahtar Kelime