Scopus
YÖKSİS Eşleşti
Kynurenine Pathway Dysregulation and Pain Perception in Acute Pancreatitis: Has the Connection Unraveled?
Neuroscience Letters · Ağustos 2024
YÖKSİS Kayıtları
Kynurenine Pathway Dysregulation and Pain Perception in Acute Pancreatitis: Has the Connection Unraveled?
Neuroscience Letters · 2024 SCI-Expanded
PROFESÖR GÖKHAN GÜNGÖR →
Kynurenine Pathway Dysregulation and Pain Perception in Acute Pancreatitis: Has the Connection Unraveled?
Neuroscience Letters · 2024 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Kynurenine Pathway Dysregulation and Pain Perception in Acute Pancreatitis: Has the Connection Unraveled?
Neuroscience Letters · 2024 SCI-Expanded
DOÇENT AHMET ÇİZMECİOĞLU →
Kynurenine Pathway Dysregulation and Pain Perception in Acute Pancreatitis: Has the Connection Unraveled?
Neuroscience Letters · 2024 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiNeuroscience Letters
Yayın TarihiAğustos 2024
Cilt / Sayfa837
Scopus ID2-s2.0-85199394388
Özet
Aim: Tryptophan (TRP), an essential amino acid, undergoes catabolism through various pathways. Notably, the kynurenine pathway (KP), constituting one of these pathways, exhibits a unidirectional impact on immune response and energy metabolism. Nonetheless, its influence on pain sensation is characterized by biphasic dynamics. This study aims to scrutinize the influence of the KP pathway on pain sensation, particularly within the context of pancreatic inflammation. Methods: Our prospective case-control study involved individuals diagnosed with acute pancreatitis and a control group matched for gender and age. The patient cohort was subsequently subdivided into severe and non-severe subgroups. To assess metabolites within KP, two blood samples were collected from the patient cohort, one at the time of diagnosis and another during the recovery phase. Furthermore, for pain quantification, daily pain scores utilizing the Visual Analog Scale (VAS) were extracted from the patients’ medical records. Results: The study incorporated 30 patients along with an equivalent number of controls. A noticeable distinction was evident between the patient and control groups, characterized by an increase in kynurenine levels and a decrease in the tryptophan/kynurenine ratio. Throughout the process of disease recovery, a uniform decrease was observed in all KP metabolites, excluding 3-Hydroxykynurenine. Elevated levels of Kynurenic acid (KYNA) were correlated with increased pain scores. Critically, no apparent distinctions in KP metabolites were discerned concerning pain severity in patients with comorbidities characterized by neural involvement. Conclusion: Based on our results, the kynurenine pathway (KP) is activated in instances of acute pancreatitis. Elevated levels of KYNA were found to be associated with heightened pain scores. The operative stages within the KP responsible for pain modulation are impaired in cases characterized by neuropathy-induced pain sensation.
Yazarlar (7)
1
Ahmet Cizmecioglu
2
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
3
Suleyman Senturk
4
Dudu Askin
5
Ali Ünlü
ORCID: 0000-0002-9991-3939
6
Huseyin Korkmaz
7
Gökhan Güngör
Anahtar Kelimeler
Acute pancreatitis
Kynurenine pathway
Pain score
Tryptophan metabolism
Kurumlar
Alanya Sifa Private Medical Center
Antalya Turkey
Selçuk Tip Fakültesi
Konya Turkey