Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues
Pharmacognosy Magazine · Ocak 2015
YÖKSİS Kayıtları
Effects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues
Pharmacognosy Magazine · 2015 SCI-Expanded 1 atıf
PROFESÖR BAHADIR ÖZTÜRK →
Makale Bilgileri
DergiPharmacognosy Magazine
Yayın TarihiOcak 2015
Cilt / Sayfa11 · 143-146
Scopus ID2-s2.0-84922110453
Erişim🔓 Açık Erişim
Özet
Objective: Investigation of possible effects of Silybum marianum extract (SME) on adenosine deaminase (ADA) activity in cancerous and noncancerous human gastric and colon tissues to obtain information about possible mechanism of anticancer action of S. marianum. Materials and Methods: Cancerous and noncancerous human gastric and colon tissues removed from patients by surgical operations were used in the studies. The extract was prepared in distilled water. Before and after treatment with the extract, ADA activities in the samples were measured. Results: ADA activity was found to be lowered significantly in cancerous gastric tissues but not in noncancerous gastric tissues after treatment with the SME. In the colon tissues, ADA activities were however found to increase after the treatment of SME. Conclusion: Our results suggest that the aqueous extract from S. marianum inhibits ADA activity in cancerous gastric tissues significantly. It is suggested that in addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA might also play a part in the anticancer properties of the S. marianum.
Yazarlar (3)
1
Bahadır Öztürk
2
Ender Hilmi Kocaoǧlu
3
Zahide Esra Durak
Anahtar Kelimeler
Adenosine deaminase
cancer
colon tissue
gastric tissue
Silybum marianum
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Ordu Üniversitesi
Ordu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
10
Atıf
3
Yazar
5
Anahtar Kelime