Scopus
YÖKSİS Eşleşti
Serum oxidant and antioxidant status of patients with chronic tension-type headache: possible effects of medical treatment
Neurological Sciences · Ekim 2015
YÖKSİS Kayıtları
Serum oxidant and antioxidant status of patients with chronic tension type headache possible effects of medical treatment
Neurological Sciences · 2015 SCI-Expanded
PROFESÖR BAHADIR ÖZTÜRK →
Makale Bilgileri
DergiNeurological Sciences
Yayın TarihiEkim 2015
Cilt / Sayfa36 · 1771-1775
Scopus ID2-s2.0-84942505583
Özet
Tension-type headache (TTH) is one of the most common and costly primary types of headache in clinical practice, with an unknown etiology. This study assessed to investigate oxidative and antioxidative status in patients with chronic tension-type headache (CTTH), and to evaluate possible effect of medical treatment. The study included 41 CTTH patients and 19 age- and sex-matched healthy subjects without headache as controls. The CTTH group comprised 20 patients receiving treatment and 21 untreated patients. We evaluated oxidant/antioxidant status by measuring serum malondialdehyde (MDA) levels and activities of antioxidant enzymes, namely glutathione peroxidase (GSH-Px) and catalase (CAT). Comparison of oxidative parameters in the patient and control groups revealed significantly lower CAT activities and higher MDA level and GSH-Px activities in the patient group. In the CTTH group, serum CAT activities were found to be significantly decreased in patient groups, while serum MDA levels and GSH-Px activities were found to be higher in the untreated CTTH patients. These findings suggest that oxidative stress is increased in the patients with CTTH, and medical treatment abolishes the stress in part. It has been concluded that antioxidant support might be helpful for the patients with CTTH to prevent oxidant stress and peroxidation damages further.
Yazarlar (8)
1
Burcu Gökçe Çokal
2
Bilal Aytaç
3
Zahide Esra Durak
4
Hafize Nalan Güneş
5
Bahadır Öztürk
6
Selda Keskin Güler
7
I. Durak
8
Tahir Kurtuluş Yoldaş
Anahtar Kelimeler
Catalase
Glutathione peroxidase
Malondialdehyde
Oxidative stress
Tension-type headache
Treatment
Kurumlar
Ankara Numune Education and Research Hospital
Ankara Turkey
Ankara Üniversitesi
Ankara Turkey
Public Health Institution of Turkey
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
T.C. Sağlık Bakanlığı,
Ankara Turkey
Metrikler
10
Atıf
8
Yazar
6
Anahtar Kelime