Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Serum prohepcidin and hepcidin levels in patients with ankylosing spondylitis: A prospective study
Journal of Clinical and Analytical Medicine · Ocak 2016
YÖKSİS Kayıtları
Serum Prohepcidin And Hepcidin Levels in Patients with Ankylosing Spondylitis A Prospective Study
Journal of Clinical and Analytical Medicine · 2016 TÜBİTAK ULAKBİM Türk Tıp Dizini
PROFESÖR BAHADIR ÖZTÜRK →
Makale Bilgileri
DergiJournal of Clinical and Analytical Medicine
Yayın TarihiOcak 2016
Cilt / Sayfa7 · 38-41
Scopus ID2-s2.0-84950106444
Erişim🔓 Açık Erişim
Özet
Aim: Anemia is a common complication in patients with inflammatory diseases such as ankylosing spondylitis. Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with ankylosing spondylitis in comparison with healthy controls. Material and Method: Forty patients with ankylosing spondylitis (13 with anemia and 27 without anemia), 20 healthy adults were prospectively enrolled. Complete blood count, erythrocyte sedimentation rate, serum levels of hepcidin, prohepcidin, iron, total iron binding capacity, ferritin, transferrin, and C-reactive protein were measured. Results: Serum levels of prohepcidin and hepcidin were significantly higher in patients with ankylosing spondylitis compared to healthy controls (p<0.005). Positive correlation was determined between the serum hepcidin and prohepcidin levels in patients with ankylosing spondylitis (r=0.725, p<0.001). Discussion: To the best of our knowledge, this is the first report of serum levels of prohepcidin and hepcidin in the patients with ankylosing spondylitis. Serum levels of prohepcidin and hepcidin are closely associated with disease activity in patients with ankylosing spondylitis and might play a role in the pathogenesis of anemia of chronic disease associated with ankylosing spondylitis.
Yazarlar (4)
1
Mehmet Dagli
2
Sema Yılmaz
ORCID: 0000-0003-4277-3880
3
Abdullah Sivrikaya
4
Bahadır Öztürk
Anahtar Kelimeler
Anemia
Ankylosing spondylitis
Hepcidin
Prohepcidin
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
3
Atıf
4
Yazar
4
Anahtar Kelime