Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
High cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissue
Bratislava Medical Journal · Ocak 2016
YÖKSİS Kayıtları
High cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissue
Bratislava Medical Journal · 2016 SCI-Expanded
PROFESÖR BAHADIR ÖZTÜRK →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiOcak 2016
Cilt / Sayfa117 · 235-241
Scopus ID2-s2.0-85014804736
Erişim🔓 Açık Erişim
Özet
OBJECTIVES: The aim of this study was to investigate possible effects of high cholesterol diet on oxidant/antioxidant status in rabbit kidney tissues. BACKGROUND: Although a number of experimental animal models have suggested that hyperlipidemia is associated with progressive kidney failure data remain sparse on the role of dietary cholesterol intake on kidney disease. METHODS: Twelve male New Zealand albino rabbits were randomly divided into two groups (control and cholesterol). Both groups were fed on a standard laboratory diet. Animals in the cholesterol group additionally received cholesterol (1 g/kg/day), orally. The study period was 12 weeks. Activities of catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), nitric oxide synthase (NOS), xanthine oxidase (XO), paraoxonase (PON), adenosine deaminase (ADA) enzymes and levels of malondialdehyde (MDA) and nitric oxide (NO) were measured in kidney tissue samples. Histological examination of the kidney tissue samples was also done. RESULTS: SOD, GSH-Px and XO enzyme activities were found to be decreased and NOS and PON activities increased significantly in cholesterol group compared to controls. As an indication of oxidation, MDA levels were found to be increased in cholesterol group. Histological examination revealed some derangements in the kidney tissue. CONCLUSION: High cholesterol diet creates oxidant load and causes peroxidation, which in turn, leads derangements in the rabbit kidney tissue.
Yazarlar (7)
1
Bahadır Öztürk
2
O. Ozer
3
Zahide Esra Durak
4
D. Billur
5
S. Kizil
6
I. Durak
7
Hasan Serdar Öztürk
Anahtar Kelimeler
Cholesterol
Kidney
Oxidant / antioxidant system
Rabbit
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Ordu Üniversitesi
Ordu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
7
Yazar
4
Anahtar Kelime