Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Impaired aortic elastic properties in patients with adult-onset hypogonadism
Blood Pressure · Nisan 2013
YÖKSİS Kayıtları
Impaired aortic elastic properties in patients with adult-onset hypogonadism
Blood Pressure · 2012 SCI
DOÇENT KADRİ MURAT GÜRSES →
Makale Bilgileri
DergiBlood Pressure
Yayın TarihiNisan 2013
Cilt / Sayfa22 · 114-119
Scopus ID2-s2.0-84875170713
Erişim🔓 Açık Erişim
Özet
Background. Recent studies have shown a strong relationship between testosterone levels and vasomotor actions. The aim of this study is to compare the elastic properties of the aorta in male patients with hypogonadism and eugonadal healthy control subjects. Method. A total of 22 male with hypogonadism (mean age: 35.2 ± 9.5 years, mean disease duration: 5.3 ± 1.8 years) and 25 age-, sex-and weight-matched eugonadal healthy subjects (mean age: 34.5 ± 8.2 years) were enrolled in the study. Aortic stiffness (β) index, aortic strain (AoS) and aortic distensibility (AoD) were calculated from the aortic diameters measured by transthoracic echocardiography and blood pressure obtained by sphygmomanometer. Results. The routinely performed echocardiographic parameters were similar between patient and control groups. There were significant differences between the control and patient groups in β index (1.75 ± 0.44 vs 2.68 ± 1.72, p < 0.001), AoS (18.52 ± 6.44 vs 12.35 ± 3.88%, p < 0.001) and AoD (7.56 ± 2.86 vs 3.96 ± 1.24, 10-6 cm2/dyn, p < 0.001). There were statistically significant positive correlations between the serum total testosterone level and AoD (r = 0.539, p < 0.001) and AoS (r = 0.372, p = 0.036); moreover, there was a negative correlation between the serum total testosterone level and β index (r =-0.462, p = 0.001). In multivariate analysis, serum total testosterone level was significantly related with AoD, AoS and β index (respectively, RR = 2.88, p = 0.004; RR = 3.45, p = 0.001; RR = 2.64, p = 0.01). Conclusion. The study results showed that aortic elasticity was impaired in patients with hypogonadism. We also have demonstrated a statistically significant correlation between aortic elastic properties and the serum total testosterone level. © 2013 Scandinavian Foundation for Cardiovascular Research.
Yazarlar (12)
1
Ugur Canpolat
ORCID: 0000-0002-4250-1706
2
Lale Tokgozoglu
3
Kadriye Aydin
4
Muhammet Dural
5
Kadri Murat Gurses
6
Hikmet Yorgun
7
Asena Gökçay Canpolat
8
Ergün Barış Kaya
9
Giray Kabakci
10
Aydan Usman
11
Mehmet Ali Oto
12
Kudret Aytemir
Anahtar Kelimeler
Aortic elastic properties
Aortic stiffness
Echocardiography
Hypogonadism
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Metrikler
7
Atıf
12
Yazar
4
Anahtar Kelime