Scopus
YÖKSİS Eşleşti
Assessment of cardiac autonomic functions by heart rate recovery, heart rate variability and QT dynamicity parameters in patients with acromegaly
Pituitary · Nisan 2014
YÖKSİS Kayıtları
Assessment of cardiac autonomic functions by heart rate recovery, heart rate variability and QT dynamicity parameters in patients with acromegaly
Pituitary · 2014 SCI-Expanded
DOÇENT KADRİ MURAT GÜRSES →
Makale Bilgileri
DergiPituitary
Yayın TarihiNisan 2014
Cilt / Sayfa17 · 163-170
Scopus ID2-s2.0-84898775121
Özet
Cardiovascular complications are the most common causes of morbidity and mortality in acromegaly. However, there is little data regarding cardiac autonomic functions in these patients. Herein, we aimed to investigate several parameters of cardiac autonomic functions in patients with acromegaly compared to healthy subjects. We enrolled 20 newly diagnosed acromegalic patients (55 % female, age:45.7 ± 12.6 years) and 32 age- and gender-matched healthy subjects. All participants underwent 24 h Holter recording. Heart rate recovery (HRR) indices were calculated by subtracting 1st, 2nd and 3rd minute heart rates from maximal heart rate. All patients underwent heart rate variability (HRV) and QT dynamicity analysis. Baseline characteristics were similar except diabetes mellitus and hypertension among groups. Mean HRR1 (29.2 ± 12.3 vs 42.6 ± 6.5, p = 0.001), HRR2 (43.5 ± 15.6 vs 61.1 ± 10.8, p = 0.001) and HRR3 (46.4 ± 16.2 vs 65.8 ± 9.8, p = 0.001) values were significantly higher in control group. HRV parameters as, SDNN [standard deviation of all NN intervals] (p = 0.001), SDANN [SD of the 5 min mean RR intervals] (p = 0.001), RMSSD [root square of successive differences in RR interval] (p = 0.001), PNN50 [proportion of differences in successive NN intervals >50 ms] (p = 0.001) and high-frequency [HF] (p = 0.001) were significantly decreased in patients with acromegaly; but low frequency [LF] (p = 0.046) and LF/HF (p = 0.001) were significantly higher in acromegaly patients. QTec (p = 0.009), QTac/RR slope (p = 0.017) and QTec/RR slope (p = 0.01) were significantly higher in patients with acromegaly. Additionally, there were significant negative correlation of disease duration with HRR2, HRR3, SDNN, PNN50, RMSSD, variability index. Our study results suggest that cardiac autonomic functions are impaired in patients with acromegaly. Further large scale studies are needed to exhibit the prognostic significance of impaired autonomic functions in patients with acromegaly. © 2013 Springer Science+Business Media.
Yazarlar (13)
1
Muhammet Dural
2
Giray Kabakci
3
Neşe Çinar
4
Tomris Erbaş
5
Ugur Canpolat
ORCID: 0000-0002-4250-1706
6
Kadri Murat Gurses
7
Lale Tokgozoglu
8
Mehmet Ali Oto
9
Ergün Barış Kaya
10
Hikmet Yorgun
11
Levent Sahiner
12
Selçuk Daǧdelen
13
Kudret Aytemir
Anahtar Kelimeler
Acromegaly
Heart rate recovery
Heart rate variability
Kurumlar
Dr. Munif Islamoglu Kastamonu State Hospital
Kastamonu Turkey
Hacettepe Üniversitesi
Ankara Turkey
Metrikler
20
Atıf
13
Yazar
3
Anahtar Kelime