Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
M2-muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation
Europace · Aralık 2014
YÖKSİS Kayıtları
M2 muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation
Europace · 2015 SCI-Expanded 8 atıf
Doç. Dr. KADRİ MURAT GÜRSES →
M2 muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation
Europace · 2015 SCI-Expanded
Doç. Dr. MUHAMMED ULVİ YALÇIN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Predictors of left atrial volume index reduction following cryoballoon-based pulmonary vein isolation
2016 ISSN: 1099-5129 SCI-Expanded
Doç. Dr. KADRİ MURAT GÜRSES →
Safety and efficacy outcomes in patients undergoing pulmonary vein isolation with second generation cryoballoon
2015 ISSN: 1099-5129 SCI-Expanded 26 atıf
Doç. Dr. KADRİ MURAT GÜRSES →
M2 muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation
2015 ISSN: 1099-5129 SCI-Expanded 8 atıf
Doç. Dr. KADRİ MURAT GÜRSES →
Predictors of left atrial volume index reduction following cryoballoon based pulmonary vein isolation
2016 ISSN: 1099-5129 SCI-Expanded
Doç. Dr. MUHAMMED ULVİ YALÇIN →
Safety and efficacy outcomes in patients undergoing pulmonary vein isolation with second generation cryoballoon
2015 ISSN: 1099-5129 SCI-Expanded
Doç. Dr. MUHAMMED ULVİ YALÇIN →
M2 muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation
2015 ISSN: 1099-5129 SCI-Expanded
Doç. Dr. MUHAMMED ULVİ YALÇIN →
The association of premature ovarian failure with ventricular repolarization dynamics evaluated by QT dynamicity
2013 ISSN: 1099-5129 SCI-Expanded
Doç. Dr. KADRİ MURAT GÜRSES →
Makale Bilgileri
Dergi
Europace
ISSN10995129
Yayın TarihiAralık 2014
Cilt / Sayfa17 · 239-246
Scopus ID2-s2.0-84922465109
Erişim🔓 Açık Erişim
Özet
Aims Atrial fibrosis has been found to be associated with recurrent atrial fibrillation (AF) following catheter ablation. Autoantibodies against M2-muscarinic receptors (anti-M2-R) may play a role in the development of AF by inducing left atrial (LA) fibrosis. In this study, we aim to compare anti-M2-R levels between paroxysmal lone AF patients and healthy control subjects and to investigate the relationship between pre-ablation anti-M2-R level, LA fibrosis quantified by delayed enhancement magnetic resonance imaging (DE-MRI), and AF recurrence following cryoablation. Methods and results Thirty-one patients with paroxysmal lone AF (53.4 ± 8.0 years, 61% male), who underwent cryoballoon-based ablation, along with 31 healthy control subjects were included. Enzyme-linked immunosorbent assay tests to measure serum anti-M2-R levels were performed in both groups and DE-MRI was done to quantify LA fibrosis prior to the ablation in the patients. Anti-M2-R levels were higher in the study population when compared with control subjects [212.4 (103.2-655.5) vs. 73.0 (39.5-299.1) ng/mL, P < 0.001]. Anti-M2-R level predicted moderate-extensive LA fibrosis independent of other measures [odds ratio: 1.26 (95% confidence interval (CI): 1.04-1.53), P = 0.017]. At a mean follow-up of 35.2 ± 3.5 months, nine patients (29.0%) had AF recurrence. In the Cox regression model including pre-ablation anti-M2-R level, LA diameter, LA volume index, and moderate-extensive LA fibrosis, only moderate-extensive LA fibrosis predicted late AF recurrence independent of other measures [hazard ratio: 29.41 (95% CI: 3.52-250.00), P = 0.002]. Conclusion Serum anti-M2-R levels may be associated with the severity of LA fibrosis and may be implicated in the pathophysiology of AF recurrence following cryoablation. Detection of anti-M2-R levels may help select appropriate patients for the procedure.
Yazarlar (13)
1
Kadri Murat Gurses
2
Muhammed Ulvi Yalçın
3
Duygu Kocyigit
4
Sacit A. Kesikli
5
Ugur Canpolat
ORCID: 0000-0002-4250-1706
6
Hikmet Yorgun
7
Mehmet Levent Şahiner
8
Ergün Barış Kaya
9
Tuncay Hazirolan
10
Necla Ozer
11
Mehmet Ali Oto
12
Dicle Guc
13
Kudret Aytemir
Anahtar Kelimeler
Atrial fibrillation
Atrial fibrosis
Cryoablation
M2-muscarinic receptor autoantibodies
Kurumlar
Ankara Yuksek Ihtisas Education and Research Hospital
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Europace
Q1
SJR Skoru3,057
H-Index137
YayıncıOxford University Press
ÜlkeUnited Kingdom
Cardiology and Cardiovascular Medicine (Q1)
Physiology (medical) (Q1)
Metrikler
30
Atıf
13
Yazar
4
Anahtar Kelime