Scopus
YÖKSİS Eşleşti
The association of serum galectin-3 levels with atrial electrical and structural remodeling
Journal of Cardiovascular Electrophysiology · Haziran 2015
YÖKSİS Kayıtları
The Association of Serum Galectin 3 Levels with Atrial Electrical and Structural Remodeling
Journal of Cardiovascular Electrophysiology · 2015 SCI 6 atıf
DOÇENT KADRİ MURAT GÜRSES →
The Association of Serum Galectin 3 Levels with Atrial Electrical and Structural Remodeling
Journal of Cardiovascular Electrophysiology · 2015 SCI-Expanded
DOÇENT MUHAMMED ULVİ YALÇIN →
Makale Bilgileri
DergiJournal of Cardiovascular Electrophysiology
Yayın TarihiHaziran 2015
Cilt / Sayfa26 · 635-640
Scopus ID2-s2.0-84930722689
Özet
Galectin-3 and Left Atrial Remodeling in AF Introduction Left atrial (LA) interstitial fibrosis is known to have a role in the initiation and maintenance of atrial fibrillation (AF). The role of galectin-3 in the pathogenesis of cardiac fibrosis has been demonstrated in previous studies. We aimed to determine whether serum galectin-3 level is associated with markers of atrial remodeling, including the extent of LA fibrosis detected by delayed enhancement magnetic resonance imaging (DE-MRI) and atrial electromechanical delay (AEMD) in paroxysmal AF patients with preserved left ventricular (LV) functions. Methods and Results Thirty-three patients (58 [28-74] years, 51.5% male) with paroxysmal AF who underwent DE-MRI prior to cryoballoon-based AF ablation were included in the study. Serum galectin-3 levels were measured with ELISA. LA volume index (B ± SE: 0.424 ± 0.504, 95% CI: 0.560-2.627, P = 0.004) and serum galectin-3 levels (B ± SE: 0.549 ± 7.745, 95% CI: 16.874-47.550, P < 0.001) were found to be independently correlated with extent of LA fibrosis detected with DE-MRI in paroxysmal AF patients with preserved LV function. Correlation analysis between AEMD parameters and baseline characteristics showed that galectin-3 was significantly correlated with intra-left (ρ = 0.432, P = 0.012) and inter-AEMD (ρ = 0.395, P = 0.023). Duration of AF, LAD, and extent of LA fibrosis were also found to be significantly correlated with AEMD parameters. Conclusion This is a hypothesis-generating study pointing out that serum galectin-3 level is significantly associated with atrial remodeling in paroxysmal AF patients with preserved LV function. Further studies are necessary to provide exact pathophysiological mechanisms.
Yazarlar (15)
1
Muhammed Ulvi Yalçın
2
Kadri Murat Gurses
3
Duygu Kocyigit
4
Hande Canpinar
5
Ugur Canpolat
ORCID: 0000-0002-4250-1706
6
Banu Evranos
7
Hikmet Yorgun
8
Mehmet Levent Şahiner
9
Ergün Barış Kaya
10
Tuncay Hazirolan
11
Lale Tokgozoglu
12
Mehmet Ali Oto
13
Necla Ozer
14
Dicle Guc
15
Kudret Aytemir
Anahtar Kelimeler
atrial electromechanical delay
atrial fibrillation
atrial fibrosis
delayed-enhancement magnetic resonance imaging
galectin-3
remodeling
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
T. C. Sağlık Bakanlığı Hakkari Devlet Hastanesi
Hakkari Turkey
Turkiye Yuksek Ihtisas Hospital
Ankara Turkey
Metrikler
70
Atıf
15
Yazar
6
Anahtar Kelime