Scopus
YÖKSİS Eşleşti
Enhanced Platelet Toll-like Receptor 2 and 4 Expression in Acute Coronary Syndrome and Stable Angina Pectoris
American Journal of Cardiology · Aralık 2015
YÖKSİS Kayıtları
Enhanced Platelet Toll like Receptor 2 and 4 Expression in Acute Coronary Syndrome and Stable Angina Pectoris
The American Journal of Cardiology · 2015 SCI 1 atıf
DOÇENT KADRİ MURAT GÜRSES →
Enhanced Platelet Toll-like Receptor 2 and 4 Expression in Acute Coronary Syndrome and Stable Angina Pectoris
The American Journal of Cardiology · 2015 SCI-Expanded
DOÇENT MUHAMMED ULVİ YALÇIN →
Makale Bilgileri
DergiAmerican Journal of Cardiology
Yayın TarihiAralık 2015
Cilt / Sayfa116 · 1666-1671
Scopus ID2-s2.0-84947331485
Özet
Evidence is accumulating that toll-like receptors (TLR) are involved in the initiation and progression of cardiovascular disease. Enhanced expression of these receptors on monocytes has been shown in patients with acute coronary syndrome (ACS). However, expression on platelets in this group of patients has not been evaluated yet. We aimed to demonstrate the possible relationship of platelet TLR-2 and TLR-4 expressions with stable coronary artery disease and ACS pathogenesis. In this observational case-control study, 40 patients diagnosed with ACS (unstable angina pectoris, non-ST-segment elevation and ST-segment elevation ACS), 40 patients diagnosed with stable coronary artery disease, and 40 age- and gender-matched subjects with normal coronary arteries were involved. Platelet TLR-2 and TLR-4 expressions were evaluated by flow cytometry in peripheral venous blood samples obtained before coronary angiography. A total of 120 patients (60.7 ± 12.3 years, 50% men) were included. Median platelet TLR-2 and TLR-4 expressions were greater in patients with ACS compared to those with stable angina pectoris and normal coronary arteries (29.5% vs 10.5% vs 3.0%, p <0.001 and 40.5% vs 11.5% vs 3.0%, p <0.001, respectively). Median platelet TLR-2 and TLR-4 expressions were also greater in patients with stable angina pectoris compared to those with normal coronary arteries (p <0.05). In conclusion, this is the first study demonstrating enhanced TLR-2 and TLR-4 expressions on platelets in patients with ACS. These findings may suggest that platelet TLR expression as a novel potential prophylactic and therapeutic target in ACS.
Yazarlar (9)
1
Kadri Murat Gurses
2
Duygu Kocyigit
3
Muhammed Ulvi Yalçın
4
Hande Canpinar
5
Mehmet Ali Oto
6
Necla Ozer
7
Lale Tokgozoglu
8
Dicle Guc
9
Kudret Aytemir
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Konya Meram Training and Research Hospital
Konya Turkey
T. C. Sağlık Bakanlığı Hakkari Devlet Hastanesi
Hakkari Turkey
Metrikler
22
Atıf
9
Yazar