Scopus
YÖKSİS Eşleşti
Association of neutrophil-to-lymphocyte ratio with the severity and morphology of coronary atherosclerotic plaques detected by multidetector computerized tomography
Acta Cardiologica Sinica · Kasım 2016
YÖKSİS Kayıtları
Association of Neutrophil to Lymphocyte Ratiowith the Severity and Morphology of CoronaryAtherosclerotic Plaques Detected byMultidetector Computerized Tomography
Acta Cardiologica Sinica · 2016 SCI-Expanded
DOÇENT MUHAMMED ULVİ YALÇIN →
Makale Bilgileri
DergiActa Cardiologica Sinica
Yayın TarihiKasım 2016
Cilt / Sayfa32 · 676-683
Scopus ID2-s2.0-84997766165
Özet
Background: Studies have demonstrated a consistent relationship between white blood cell (WBC) counts and coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR) has been considered as a potential marker for identifying individuals under risk of CAD and associated events. In this study, we aimed to evaluate whether NLR was associated with the severity and morphology of coronary atherosclerotic plaques shown by multidetector computed tomography (MDCT). Methods: Our study population consisted of 684 patients who underwent dual-source 64 slice MDCT for the assessment of CAD. Coronary arteries were evaluated on a 16-segment basis and critical coronary plaque was described as luminal narrowing > 50%, whereas plaque morphology was assessed on a per segment basis. Total WBC, neutrophil and lymphocyte counts were determined using commercially available assay kits. Results: WBC count [7700 (6400-8800) vs. 6800 (5700-7900), p < 0.05] and NLR [2.40 (1.98-3.07) vs. 1.86 (1.50- 2.38), p < 0.001] were found to be higher in patients with critical stenosis than in those without. In the binary logistic regression analysis, NLR was a predictor of critical stenosis (odds ratio, 1.68; 95% confidence interval, 1.39-2.03, p < 0.001). NLR levels differed among plaque morphology subtypes (p < 0.05) and was significantly higher in non-calcified plaque (NCP) compared to mixed plaque (MP) and calcified plaque (CP) (p < 0.05). In the multinomial logistic regression analysis, NLR was found to be an independent predictor of NCP,MP and CP (p < 0.001). Conclusions: These data show that NLR is associated with both the severity and morphology of coronary atherosclerotic disease.
Yazarlar (9)
1
Ahmet Hakan Ateş
2
Kudret Aytemir
3
Duygu Kocyigit
4
Muhammed Ulvi Yalçın
5
Kadri Murat Gurses
6
Hikmet Yorgun
7
Ugur Canpolat
ORCID: 0000-0002-4250-1706
8
Tuncay Hazirolan
9
Necla Ozer
Anahtar Kelimeler
Atherosclerosis
Coronary plaque
Inflammation
Multidetector computerized tomography
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Samsun Training and Research Hospital
Samsun Turkey
Metrikler
24
Atıf
9
Yazar
4
Anahtar Kelime