Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Serum galectin-3 level as a marker of thrombogenicity in atrial fibrillation
Journal of Clinical Laboratory Analysis · Kasım 2017
YÖKSİS Kayıtları
Serum galectin-3 level as a marker of thrombogenicity in atrial fibrillation
Journal of Clinical Laboratory Analysis · 2017 SCI
DOÇENT KADRİ MURAT GÜRSES →
Serum galectin-3 level as a marker of thrombogenicity in atrial fibrillation
Journal of Clinical Laboratory Analysis · 2017 SCI-Expanded
DOÇENT MUHAMMED ULVİ YALÇIN →
Makale Bilgileri
DergiJournal of Clinical Laboratory Analysis
Yayın TarihiKasım 2017
Cilt / Sayfa31
Scopus ID2-s2.0-85015211819
Erişim🔓 Açık Erişim
Özet
Background: Left atrial appendage flow velocity (LAAFV) and presence of spontaneous echo contrast (SEC) have been reported to be predictors of thromboembolism in atrial fibrillation (AF) patients. Galectin-3 is a biomarker reflecting pro-inflammatory status, whose role in AF has recently drawn attention, particularly in persistent AF population. Aim: In this study we aimed to investigate the association between serum galectin-3 levels and echocardiographic predictors of thromboembolism in persistent AF patients. Methods: We included 65 persistent AF patients (55.50±10.67 years, 46.15% male). Transesophageal echocardiography (TEE) was performed to assess LAAFV and presence of left atrial (LA)/LA appendage (LAA)-located SEC and thrombus prior to direct current cardioversion or catheter ablation for AF. Results: Median galectin-3 level was 0.63 ng/mL. Serum galectin-3 levels were significantly correlated with LAAFV (r=−.440, P<.001). Serum galectin-3 levels were associated with presence of SEC (P<.001), and LA thrombus (P=.008). Receiver operating characteristic analysis revealed that a serum galectin-3 greater or equal to the cut-off value of 0.69 predicted presence of SEC with a sensitivity and specificity of 91.00% and 79.00%, respectively (P<.001). Conclusion: In conclusion, in the setting of persistent AF, serum galectin-3 levels are associated with presence of SEC and LAAFV on TEE. Our findings suggest that serum galectin-3 level may have a place in thromboembolism risk stratification in persistent AF patients.
Yazarlar (10)
1
Duygu Kocyigit
2
Kadri Murat Gurses
3
Muhammed Ulvi Yalçın
4
Hande Canpinar
5
Ugur Canpolat
ORCID: 0000-0002-4250-1706
6
Banu Evranos
7
Hikmet Yorgun
8
Necla Ozer
9
Dicle Guc
10
Kudret Aytemir
Anahtar Kelimeler
atrial fibrillation
galectin-3
left atrial appendage flow velocity
transesophageal echocardiography
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Konya Meram Training and Research Hospital
Konya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
12
Atıf
10
Yazar
4
Anahtar Kelime