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Enhanced serum levels of matrix Gla protein and bone morphogenetic protein in acute coronary syndrome patients

Journal of Clinical Laboratory Analysis · Mart 2018

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YÖKSİS Kayıtları
Enhanced serum levels of matrix Gla protein and bone morphogenetic protein in acute coronary syndrome patients
JOURNAL OF CLINICAL LABORATORY ANALYSIS · 2018 SCI
Doç. Dr. KADRİ MURAT GÜRSES →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 8 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Serum and Saliva Levels of Ischemia Modified Albumin in Patients with Acute Myocardial Infarction
2013 ISSN: 08878013 SCI-Expanded
Prof. Dr. FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Evaluation of Netrin 1 Levels and Albuminuria in Patients With Diabetes
2016 ISSN: 08878013 SCI
Prof. Dr. ALİ ÜNLÜ →
Serum galectin-3 level as a marker of thrombogenicity in atrial fibrillation
2017 ISSN: 08878013 SCI-Expanded Q3
Doç. Dr. MUHAMMED ULVİ YALÇIN →
Evaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetes
2016 ISSN: 08878013 SCI-Expanded
Prof. Dr. KAMİLE MARAKOĞLU →
Serum galectin-3 level as a marker of thrombogenicity in atrial fibrillation
2017 ISSN: 08878013 SCI
Doç. Dr. KADRİ MURAT GÜRSES →
Enhanced serum levels of matrix Gla protein and bone morphogenetic protein in acute coronary syndrome patients
2018 ISSN: 0887-8013 SCI
Doç. Dr. KADRİ MURAT GÜRSES →
Investigation of the Levels of Serum Amyloid A, YKL-40, and Pentraxin-3 in Patients with Familial Mediterranean Fever
2016 ISSN: 08878013 SCI
Prof. Dr. YASEMİN COŞKUN YAVUZ →
The importance of serum biglycan levels as a fibrosis marker in patients with chronic hepatitis B
2016 ISSN: 0887-8013 SCI-Expanded Q3
Prof. Dr. RAFİYE ÇİFTÇİLER →

Makale Bilgileri

Dergi Journal of Clinical Laboratory Analysis
ISSN08878013
Yayın TarihiMart 2018
Cilt / Sayfa32
DOI10.1002/jcla.22278
Scopus ID2-s2.0-85020401563
Erişim🔓 Açık Erişim
Özet Background: Vascular calcification has been found to be associated with increased risk of cardiovascular (CV) morbidity and mortality. Various bone-associated proteins have been suggested to be related with this process. In this study, we aimed to evaluate whether serum levels of bone morphogenic protein-4 (BMP-4) and matrix Gla protein (MGP) differed in patients who were found to have normal epicardial coronary arteries or a culprit lesion in the coronary angiography leading to acute coronary syndrome (ACS). Methods: Patients admitted to emergency department with the diagnosis of ACS who underwent primary percutaneous coronary intervention (PCI) between October 2015 and April 2016 were consecutively recruited as the patient group. Age and gender-matched subjects who underwent coronary angiography following non-invasive ischemia assessment made the control group. Results: A total of 90 subjects (63.00±14.02 years, 70% male) were included in this study. MGP (<0.001) and BMP-4 (<0.001) levels were significantly elevated when compared to subjects with normal coronary arteries. Fasting blood glucose (P=.024), HDL-cholesterol (P=.002), C-reactive protein (CRP) (P=.001) levels, and left ventricular ejection fraction (LVEF) (P=.021) were significantly correlated with serum MGP levels. HDL-cholesterol (P=.001) and CRP (P=.030) levels were also significantly correlated with serum BMP-4 levels. In the model including HDL-cholesterol, CRP, MGP, and BMP-4 levels, only MGP (odds ratio[OR]: 1.018, P=.019) and BMP-4 (OR: 1.313, P=.023) were found to be independently associated with ACS. Conclusion: This study shows that serum BMP-4 and MGP are independently associated with ACS occurrence when adjusted for other CV risk factors. These biomarkers may have a diagnostic potential in ACS patients.

Yazarlar (8)

1
Zafer Buyukterzi
2
Ümmügülsüm Can
3
Sertac Alpaydin
4
Asuman Guzelant
5
Sukru Karaarslan
6
Mehmet Mustu
7
Duygu Kocyigit
8
Kadri Murat Gurses

Anahtar Kelimeler

acute coronary syndrome atherosclerosis biomarker bone morphogenetic protein matrix Gla protein

Kurumlar

Hacettepe Üniversitesi
Ankara Turkey
Konya Meram Training and Research Hospital
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Clinical Laboratory Analysis
Q1 OA
SJR Skoru0,847
H-Index71
YayıncıWiley-Liss Inc.
ÜlkeUnited States
Medical Laboratory Technology (Q1)
Biochemistry (medical) (Q2)
Clinical Biochemistry (Q2)
Hematology (Q2)
Immunology and Allergy (Q2)
Microbiology (medical) (Q2)
Public Health, Environmental and Occupational Health (Q2)
Dergi sayfasına git

Metrikler

7
Atıf
8
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

KG
KADRİ MURAT GÜRSES
Doç. Dr.

Hızlı Erişim

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