Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients
Cytokine · Mart 2018
YÖKSİS Kayıtları
Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients
CYTOKINE · 2018 SCI
Doç. Dr. MUHAMMED ULVİ YALÇIN →
Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients
CYTOKINE · 2018 SCI
Doç. Dr. KADRİ MURAT GÜRSES →
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Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients
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Makale Bilgileri
Dergi
Cytokine
ISSN10434666
Yayın TarihiMart 2018
Cilt / Sayfa103 · 50-56
Scopus ID2-s2.0-85040105587
Özet
Background Atrial fibrillation(AF) is the most common sustained arrhythmia. Its most feared sequelae are stroke and peripheral thromboembolism due to atrial thrombi formation. Mechanisms underlying the relationship between platelet activation and left atrial thrombi have not been clearly elucidated yet. We aimed to investigate whether immune-mediated platelet activation occurred in AF patients in this cross-sectional study. Methods Persistent and paroxysmal AF patients who underwent cryoballoon-based AF ablation between March 2015 and July 2016 were included as the patient group. Patients without AF in whom transseptal puncture was performed at the same period for purposes other than AF ablation were included as the control group. Peripheral and left atrial blood samples were obtained for determination of platelet Toll-like receptor(TLR)-2, TLR-4 and high mobility group box-1(HMGB-1) expression levels. Results A total of 75 subjects (53 patients with AF and 22 control subjects) [mean: 60.33 (SD: 6.14) years, 57.33% male] were included. Left atrial and peripheral TLR-2, 4 and HMGB-1 expression levels were significantly higher in the patient group when compared to the controls. Left atrial platelet TLR-2 and TLR-4 expression and serum HMGB-1 levels were higher in persistent AF patients compared to paroxysmal AF patients. In the patient group, left atrial expression of TLR-2, 4 and HMGB-1 were significantly higher than the peripheral expression levels. Conclusion Findings of our study suggest evidence for immune-mediated platelet activation in the left atria of AF patients.
Yazarlar (10)
1
Kadri Murat Gurses
2
Duygu Kocyigit
3
Muhammed Ulvi Yalçın
4
Hande Canpinar
5
Banu Evranos
6
Ugur Canpolat
ORCID: 0000-0002-4250-1706
7
Hikmet Yorgun
8
Levent Sahiner
9
Dicle Guc
10
Kudret Aytemir
Anahtar Kelimeler
Atrial fibrillation
Immunity
Platelets
Thrombosis
Toll-like receptor
Kurumlar
Aydin Adnan Menderes University
Aydin Turkey
Dinar Devlet Hastanesi
Dinar Turkey
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Cytokine
Q1
SJR Skoru1,083
H-Index147
YayıncıAcademic Press
ÜlkeUnited States
Hematology (Q1)
Biochemistry (Q2)
Immunology (Q2)
Immunology and Allergy (Q2)
Molecular Biology (Q2)
Metrikler
13
Atıf
10
Yazar
5
Anahtar Kelime