Scopus
YÖKSİS Eşleşti
Vitamin D replacement ameliorates serum lipoprotein functions, adipokine profile and subclinical atherosclerosis in pre-menopausal women
Nutrition, Metabolism and Cardiovascular Diseases · Ağustos 2018
YÖKSİS Kayıtları
Vitamin D replacement ameliorates serum lipoprotein functions, adipokine profile and subclinical atherosclerosis in pre-menopausal women
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES · 2018 SCI
DOÇENT KADRİ MURAT GÜRSES →
Makale Bilgileri
DergiNutrition, Metabolism and Cardiovascular Diseases
Yayın TarihiAğustos 2018
Cilt / Sayfa28 · 822-829
Scopus ID2-s2.0-85048990370
Özet
Background and aims: Low vitamin D (vitD) has been linked to increased cardiovascular (CV) risk, but the effects of vitD supplementation are not clarified. We evaluated the impact of vitD normalization on HDL cholesterol efflux capacity (CEC), which inversely correlates with CV risk, the proatherogenic serum cholesterol loading capacity (CLC), adipokine profile and subclinical atherosclerosis. Methods and results: Healthy premenopausal women with vitD deficiency (n = 31) underwent supplementation. Subclinical atherosclerosis was evaluated by flow-mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AIx), measured with standard techniques. HDL CEC and serum CLC were measured by a radioisotopic and fluorimetric assay, respectively. Malondialdehyde (MDA) in HDL was quantified by the TBARS assay. Pre-β HDL was assessed by 2D-electrophoresis. Serum adipokines were measured by ELISA. VitD replacement restored normal levels of serum 25-hydroxyvitamin D (25OHD) and significantly improved FMD (+4%; p < 0.001), PWV (−4.1%: p < 0.001) and AIx (−16.1%; p < 0.001). Total CEC was significantly improved (+19.5%; p = 0.003), with a specific increase in the ABCA1-mediated CEC (+70.8%; p < 0.001). HDL-MDA slightly but significantly decreased (−9.6%; p = 0.027), while no difference was detected in pre-β HDL. No change was observed in aqueous diffusion nor in the ABCG1-mediated CEC. Serum CLC was significantly reduced (−13.3%; p = 0.026). Levels of adiponectin were increased (+50.6%; p < 0.0001) and resistin levels were decreased (−24.3%; p < 0.0001). After vitD replacement, an inverse relationship was found linking the ABCA1-mediated CEC with pre-β HDL (r2 = 0.346; p < 0.001) and resistin (r2 = 0.220; p = 0.009). Conclusion: Our data support vitD supplementation for CV risk prevention.
Yazarlar (15)
1
D. Greco
2
Duygu Kocyigit
3
M. P. Adorni
4
Cinzia Marchi
5
N. Ronda
6
F. Bernini
ORCID: 0000-0002-2576-7983
7
Kadri Murat Gurses
8
Hande Canpinar
9
Dicle Guc
10
S. H. Oguz
11
A. Gurlek
12
A. Strazzella
13
S. Simonelli
14
Lale Tokgozoglu
15
Francesca Zimetti
Anahtar Kelimeler
Adiponectin
Atherosclerosis
Cholesterol efflux capacity
HDL
Macrophage
Resistin
Vitamin D
Kurumlar
Aydin Adnan Menderes University
Aydin Turkey
Dinar Devlet Hastanesi
Dinar Turkey
Hacettepe Üniversitesi
Ankara Turkey
Università degli Studi di Milano
Milan Italy
Università di Parma
Parma Italy
University of Health Sciences
Istanbul Turkey
Metrikler
17
Atıf
15
Yazar
7
Anahtar Kelime