Scopus
YÖKSİS Eşleşti
Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis
Acta Cardiologica · Ocak 2021
YÖKSİS Kayıtları
Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis
Acta Cardiologica · 2021 SCI-Expanded
DOÇENT KADRİ MURAT GÜRSES →
Makale Bilgileri
DergiActa Cardiologica
Yayın TarihiOcak 2021
Cilt / Sayfa76 · 544-552
Scopus ID2-s2.0-85097749795
Özet
Background: Histopathological changes in calcific aortic stenosis (CAS) resemble changes in coronary atherosclerosis. Concerning recent evidence on dietary and gut microbiota-related metabolites representing players in atherosclerosis, we aimed to investigate the link between dietary and gut microbiota-derived metabolites and CAS. Methods: We consecutively recruited eligible subjects with moderate-severe CAS (n = 60), aortic sclerosis (ASc) (n = 49) and age and gender-matched control subjects (n = 48) in May 2016-December 2016. Plasma dietary and gut microbiota-related metabolite levels, namely choline, betaine, and trimethylamine N-oxide (TMAO), were measured using ultra-performance liquid chromatography-tandem mass spectroscopy method. Histopathological examinations were performed in patients that underwent aortic valve surgery. Results: Prevalence of traditional cardiovascular risk factors or co-morbidities did not differ among groups (all p > 0.05). CAS patients had higher plasma choline levels compared to both control (p < 0.001) and ASc (p = 0.006). Plasma betaine and TMAO levels were similar (both p > 0.05). Compared to the lowest quartile choline levels (<11.15 μM), patients with the highest quartile choline levels (≥14.98 μM) had higher aortic valvular (p < 0.001) and mitral annular (p = 0.013) calcification scores. Plasma choline levels were independently associated with aortic peak flow velocity (B ± SE:0.165 ± 0.060, p = 0.009). Choline levels were elevated in subjects who had aortic valves with denser lymphocyte infiltration (p < 0.001), neovascularization (p = 0.011), osseous metaplasia (p = 0.004), more severe tissue remodelling (p = 0.002) and calcification (p = 0.002). Conclusion: We found a significant association between choline levels and CAS presence and severity depicted on imaging modalities and histopathological examinations. Our study may open new horizons for prevention of CAS.
Yazarlar (11)
1
Duygu Kocyigit
2
Lale Tokgozoglu
ORCID: 0000-0001-6441-3339
3
Kadri Murat Gurses
4
Marcus Ståhlman
5
Jan Borén
6
Mehmet F.T. Soyal
ORCID: 0000-0001-6276-3140
7
Hande Canpinar
8
Dicle Guc
9
Arzu Saglam Ayhan
ORCID: 0000-0002-0076-8293
10
Tuncay Hazirolan
11
Necla Ozer
Anahtar Kelimeler
betaine
Calcific aortic stenosis
choline
trimethylamine N-oxide
Kurumlar
Ankara Numune Hospital
Ankara Turkey
Aydin Adnan Menderes University
Aydin Turkey
Göteborgs Universitet
Gothenburg Sweden
Hacettepe Üniversitesi
Ankara Turkey
Metrikler
11
Atıf
11
Yazar
4
Anahtar Kelime