Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Cholesterol efflux promoting function of high-density lipoproteins in calcific aortic valve stenosis
Atherosclerosis Plus · Ekim 2021
YÖKSİS Kayıtları
Cholesterol efflux promoting function of high-density lipoproteins in calcific aortic valve stenosis
Atherosclerosis Plus · 2021 Directory of Open Access Journals (DOAJ)
DOÇENT KADRİ MURAT GÜRSES →
Cholesterol efflux promoting function of high-density lipoproteins in calcific aortic valve stenosis
Atherosclerosis Plus · 2021 SCI-Expanded
DOÇENT KADRİ MURAT GÜRSES →
Makale Bilgileri
DergiAtherosclerosis Plus
Yayın TarihiEkim 2021
Cilt / Sayfa44 · 18-24
Scopus ID2-s2.0-85120695022
Erişim🔓 Açık Erişim
Özet
Background and aims: Cholesterol efflux capacity is a functional property of high-density lipoproteins (HDL) reflecting the efficiency of the atheroprotective reverse cholesterol transport process in humans. Its relationship with calcific aortic valve stenosis (CAVS) has not been fully assessed yet. Methods: We evaluated HDL-CEC in a patient population with varying degrees of aortic valvular calcific disease, assessed using echocardiography and cardiac computed tomography. Measurement of biomarkers that reflect osteogenic and tissue remodeling, along with dietary and gut microbiota-derived metabolites were performed. Results: Patients with moderate-severe CAVS had significantly lower HDL-CEC compared to both control and aortic sclerosis subjects (mean: 6.09%, 7.32% and 7.26%, respectively). HDL-CEC displayed negative correlations with peak aortic jet velocity and aortic valve calcium score, indexes of CAVS severity (ρ = -0.298, p = 0.002 and ρ = -0.358, p = 0.005, respectively). In multivariable regression model, HDL-CEC had independent association with aortic valve calcium score (B: -0.053, SE: 0.014, p < 0.001), GFR (B: -0.034, SE: 0.012, p = 0.007), as well as with levels of total cholesterol (B: 0.018, SE: 0.005, p = 0.002). Conclusion: These results indicate an impairment of HDL-CEC in moderate-severe CAVS and may contribute to identify potential novel targets for CAVS management.
Yazarlar (13)
1
Duygu Kocyigit
2
Francesca Zimetti
3
Kadri Murat Gurses
4
Ilaria Zanotti
5
Cinzia Marchi
6
Marcus Ståhlman
7
Jan Borén
8
Hande Canpinar
9
Mehmet F.T. Soyal
10
Dicle Guc
11
Tuncay Hazirolan
12
Necla Ozer
13
Lale Tokgozoglu
ORCID: 0000-0001-6441-3339
Anahtar Kelimeler
Aortic stenosis
Aortic valve calcium score
Choline
Lipids
Matrix metalloproteinase
Kurumlar
Ankara Numune Hospital
Ankara Turkey
Aydin Adnan Menderes University
Aydin Turkey
Göteborgs Universitet
Gothenburg Sweden
Hacettepe Üniversitesi
Ankara Turkey
Università di Parma
Parma Italy
Metrikler
2
Atıf
13
Yazar
5
Anahtar Kelime