Scopus
YÖKSİS Eşleşti
Effects of bone marrow-derived mesenchymal stem cells on doxorubicin-induced liver injury in rats
Journal of Biochemical and Molecular Toxicology · Nisan 2022
YÖKSİS Kayıtları
Effects of bone marrow‐derived mesenchymal stem cells on doxorubicin‐induced liver injury in rats
Journal of Biochemical and Molecular Toxicology · 2022 SCI-Expanded
DOÇENT KADRİ MURAT GÜRSES →
Makale Bilgileri
DergiJournal of Biochemical and Molecular Toxicology
Yayın TarihiNisan 2022
Cilt / Sayfa36
Scopus ID2-s2.0-85125402382
Özet
Doxorubicin (DOX) is a potent chemotherapeutic agent and has toxic effects on various organs, including the liver. In the current study, we aimed to investigate the effects of bone-marrow-derived mesenchymal stem cell (BM-MSC) administration on DOX-induced hepatotoxicity in rats. 24 Wistar-albino rats were divided into three groups: Control, DOX, and DOX+MSC. DOX (20 mg/kg) was administered to the DOX group. In the DOX + MSC group, BM-MSCs (2 × 106) were given through the tail vein following DOX administration. DOX administration led to significant structural liver injury. Besides this, oxidative balance in the liver was impaired following DOX administration. DOX administration also led to an increase in apoptotic cell death in the liver. Structural and oxidative changes were significantly alleviated with the administration of BM-MSCs. Furthermore, BM-MSC administration suppressed excessive apoptotic cell death. Our findings revealed that BM-MSC administration may alleviate DOX-induced liver injury via improving the oxidative status and limiting apoptotic cell death in the liver tissue.
Yazarlar (6)
1
Tugba Celik Samanci
ORCID: 0000-0002-5063-8104
2
Alpaslan Gökcimen
ORCID: 0000-0003-4382-5443
3
Mehtap Kilic Eren
ORCID: 0000-0003-3830-8775
4
Kadri Murat Gurses
5
Hatice Pilevneli
ORCID: 0000-0003-1455-7283
6
Yurdun Kuyucu
ORCID: 0000-0001-6289-0860
Anahtar Kelimeler
apoptosis
Doxorubicin
liver toxicity
mesenchymal stem cells
oxidative stress
Kurumlar
Aydin Adnan Menderes University
Aydin Turkey
Çukurova Üniversitesi Tip Fakültesi
Adana Turkey
Recep Tayyip Erdogan University
Rize Turkey
Metrikler
3
Atıf
6
Yazar
5
Anahtar Kelime