Scopus
YÖKSİS Eşleşti
Protective effect of infliximab on ischemia/reperfusion-induced damage in rat kidney
Renal Failure · Ekim 2012
YÖKSİS Kayıtları
Protective Effect of Infliximab on Ischemia/Reperfusion-Induced Damage in Rat Kidney
RENAL FAİLURE · 2012 SCI
DOKTOR ÖĞRETİM ÜYESİ MERVE GÖKŞİN KARAASLAN TUNÇ →
Makale Bilgileri
DergiRenal Failure
Yayın TarihiEkim 2012
Cilt / Sayfa34 · 1144-1149
Scopus ID2-s2.0-84866401335
Özet
Objective: To investigate the protective effect of infliximab on ischemiareperfusion (I/R) injury of the rat kidney. Methods: Twenty-eight male Wistar albino rats were divided into four groups: sham-operated, I/R, I/R with infliximab administered before ischemia [I/R infliximab (bi)], and I/R with infliximab administered before reperfusion [I/R infliximab (br)]. After a right nephrectomy to produce damage, the left renal vessels were occluded for 60 min, followed by 24-h reperfusion in rats. Changes in the rat kidney were observed by measuring the tissue levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), and superoxide dismutase (SOD) and by evaluating hematoxylineosin (H&E)-stained and periodic acidSchiff (PAS) sections. Results: The MDA and MPO levels in the I/R group were significantly higher than in the other groups (p < 0.05), and the SOD and GSH levels in the I/R infliximab (bi) and I/R infliximab (br) groups were significantly higher than in the I/R group (p < 0.05). However, histological examination revealed that the I/R infliximab (bi) group and the I/R infliximab (br) group had significantly fewer tubular changes and interstitial inflammatory cell infiltration than the I/R group. Conclusion: These results show that infliximab may protect against I/R injury in the rat I/R model. © 2012 Informa Healthcare USA, Inc.
Yazarlar (8)
1
Cemal Tasdemir
2
Seda Tasdemir
3
Nigar Vardi
ORCID: 0000-0003-0576-1696
4
Burhan Ates
ORCID: 0000-0001-6080-229X
5
Hakan Parlakpinar
ORCID: 0000-0001-9497-3468
6
Bulent Kati
7
Merve Gökşin Karaaslan
8
Ahmet Acet
Anahtar Kelimeler
Infliximab
Ischemiareperfusion
Renal
Kurumlar
Inönü Üniversitesi
Malatya Turkey
Medical Faculty
Malatya Turkey
Metrikler
34
Atıf
8
Yazar
3
Anahtar Kelime