Scopus
YÖKSİS Eşleşti
Design of Xylose-Based Semisynthetic Polyurethane Tissue Adhesives with Enhanced Bioactivity Properties
ACS Applied Materials and Interfaces · Şubat 2016
YÖKSİS Kayıtları
Design of Xylose-Based Semisynthetic Polyurethane Tissue Adhesives with Enhanced Bioactivity Properties
ACS APPLIED MATERIALS INTERFACES · 2016 SCI
DOKTOR ÖĞRETİM ÜYESİ MERVE GÖKŞİN KARAASLAN TUNÇ →
Makale Bilgileri
DergiACS Applied Materials and Interfaces
Yayın TarihiŞubat 2016
Cilt / Sayfa8 · 4456-4466
Scopus ID2-s2.0-84962528552
Özet
Developing biocompatible tissue adhesives with high adhesion properties is a highly desired goal of the tissue engineering due to adverse effects of the sutures. Therefore, our work involves synthesis, characterization, adhesion properties, protein adsorption, in vitro biodegradation, in vitro and in vivo biocompatibility properties of xylose-based semisynthetic polyurethane (NPU-PEG-X) bioadhesives. Xylose-based semisynthetic polyurethanes were developed by the reaction among 4,4′-methylenebis(cyclohexyl isocyanate) (MCI), xylose and polyethylene glycol 200 (PEG). Synthesized polyurethanes (PUs) showed good thermal stability and high adhesion strength. The highest values in adhesion strength were measured as 415.0 ± 48.8 and 94.0 ± 2.8 kPa for aluminum substrate and muscle tissue in 15% xylose containing PUs (NPU-PEG-X-15%), respectively. The biodegradation of NPU-PEG-X-15% was also determined as 19.96 ± 1.04% after 8 weeks of incubation. Relative cell viability of xylose containing PU was above 86%. Moreover, 10% xylose containing NPU-PEG-X (NPU-PEG-X-10%) sample has favorable tissue response, and inflammatory reaction between 1 and 6 weeks implantation period. With high adhesiveness and biocompatibility properties, NPU-PEG-X can be used in the medical field as supporting materials for preventing the fluid leakage after abdominal surgery or wound closure.
Yazarlar (9)
1
Sevgi Balcioglu
ORCID: 0000-0003-0724-4772
2
Hakan Parlakpinar
ORCID: 0000-0001-9497-3468
3
Nigar Vardi
ORCID: 0000-0003-0576-1696
4
Emir Baki Denkbas
5
Merve Gökşin Karaaslan
6
Selam Gulgen
7
E. Taslidere
8
Suleyman Koytepe
ORCID: 0000-0002-4788-278X
9
Burhan Ates
ORCID: 0000-0001-6080-229X
Anahtar Kelimeler
biocompatibility
polyurethane
semisynthetic materials
tissue adhesive
xylose
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Inönü Üniversitesi
Malatya Turkey
Metrikler
51
Atıf
9
Yazar
5
Anahtar Kelime