Scopus
YÖKSİS Eşleşti
Effects of melatonin on acetylsalicylic acid induced gastroduodenal and jejunal mucosal injury
Biotechnic and Histochemistry · Ekim 2018
YÖKSİS Kayıtları
Effects of melatonin on acetylsalicylic acid induced gastroduodenal and jejunal mucosal injury
Biotechnic & Histochemistry · 2018 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MERVE GÖKŞİN KARAASLAN TUNÇ →
Makale Bilgileri
DergiBiotechnic and Histochemistry
Yayın TarihiEkim 2018
Cilt / Sayfa93 · 485-495
Scopus ID2-s2.0-85056159548
Özet
We evaluated the effects of melatonin on acetylsalicylic acid (ASA) induced gastroduodenal and jejunal mucosal injury. We used 40 postpubertal rats divided randomly into five groups of eight animals. The control group consisted of untreated animals. The Mel group was injected intraperitoneally (i.p.) with 5 mg/kg melatonin. The ASA group was injected i.p. with 200 mg/kg ASA. The ASA + Mel group was injected i.p. with 5 mg/kg melatonin 45 min after administering 200 mg/kg ASA i.p. The Mel + ASA group was injected i.p. with 5 mg/kg melatonin 45 min before administering 200 mg/kg ASA i.p. We found no statistically significant differences in mean histopathological scores in the ASA + Mel group compared to the ASA group. ASA caused shortened villi and loss of the apical villus in the duodenum. The histopathological score was increased and villus height was decreased in the ASA group compared to untreated controls. Treatment with melatonin attenuated the histological damage. In the ASA group, occasional areas showed erosion of villi in the jejunum; however, differences in mean histopathological score in ASA group compared to the other groups were not statistically significant. Malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) activities were measured in stomach, duodenal and jejunum tissue. We found increased MDA activity in both stomach and duodenal tissues in the ASA group compared to the control group (p < 0.05). We found no statistically significant changes in MDA levels in jejunal tissue in the ASA group compared to the control group. We found no change in SOD activity in either stomach or duodenal tissues in the ASA group compared to the control group. We observed decreased SOD activity in jejunal tissue in the ASA group compared to the control group (p < 0.05). We detected no change in GSH activity in stomach, duodenal or jejunal tissues in the ASA group compared to the control group. The stomach damage was less in melatonin treated groups, but the lesions were not completely eliminated. The jejunum in the ASA group retained a nearly normal appearance. We found that melatonin exhibited some healing effects on ASA induced duodenal mucosal injury.
Yazarlar (6)
1
E. Taslidere
2
Nigar Vardi
ORCID: 0000-0003-0576-1696
3
Hakan Parlakpinar
ORCID: 0000-0001-9497-3468
4
Azibe Yildiz
ORCID: 0000-0001-5686-7867
5
B. Taslidere
6
Merve Gökşin Karaaslan
Anahtar Kelimeler
acetylsalicylic acid
aspirin
duodenum
jejunum
melatonin
rat
stomach
Kurumlar
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Inönü Üniversitesi
Malatya Turkey
T.C. Sağlık Bakanlığı Malatya Devlet Hastanesi
Malatya Turkey
Metrikler
2
Atıf
6
Yazar
7
Anahtar Kelime