Scopus
Chemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitors
Bioorganic Chemistry · Ocak 2020
Makale Bilgileri
DergiBioorganic Chemistry
Yayın TarihiOcak 2020
Cilt / Sayfa95
Scopus ID2-s2.0-85078192450
Özet
In recent years, the preparation of metal complexes and the introduction of biologically active organometalic compounds are new strategies in drug development. For this purpose, generally N-heterocyclic pharmaceutical agents have been used as promising nuclei. Au-containing N-heterocyclic carbene (Au-NHC) derivatives are among the compounds used for this purpose, and their enzyme inhibition, antioxidant activity, antimicrobial and anticancer properties are widely studied. In these studies, the anticancer property of Au-NHC complexes is the most widely studied area. The common result in different studies has been revealed that mitochondrial thioredoxin reductases (TrxR) inhibition is the main pathway in the powerful anticancer effect of many Au-NHC complexes. In TrxR inhibition, the high affinity of gold to sulfur is considered to be the main component of the effect. This review includes the discussions releated to the anticancer activities and TrxR inhibition properties of Au-NHC compounds.
Yazarlar (5)
1
Merve Gökşin Karaaslan
2
Aydın Aktaş
3
Canbolat Gürses
ORCID: 0000-0002-4085-0224
4
Yetkin Gök
5
Burhan Ates
ORCID: 0000-0001-6080-229X
Anahtar Kelimeler
Anticancer activity
Au-NHC complexes
Enzyme
TrxR inhibitors
Kurumlar
Inönü Üniversitesi
Malatya Turkey
Metrikler
51
Atıf
5
Yazar
4
Anahtar Kelime