Scopus
🔓 Açık Erişim
Enhancing the nanoplasmonic signal by a nanoparticle sandwiching strategy to detect viruses
Applied Materials Today · Eylül 2020
Makale Bilgileri
DergiApplied Materials Today
Yayın TarihiEylül 2020
Cilt / Sayfa20
Scopus ID2-s2.0-85086579504
Erişim🔓 Açık Erişim
Özet
Nanoparticles that can assemble and bind selectively on surfaces in intricate geometries can trigger multiple plasmonic modalities and enable wide applications in agriculture such as pesticide monitoring, in medical imaging such as targeted cancer detection, in bioengineering such as biotarget detection and biosensing, and in healthcare such as selection of drugs and their binding kinetics. However, these particles mainly rely on binding of the target to a surface to create a plasmonic resonance and subsequent shifts by binding of biotargets, which limit the flexibility to control overall sensitivity. Here, we present an unconventional way that sandwiches a virus (i.e., Hepatitis B virus: HBV) topographically between two or more nanoparticles on the top and the bottom to create a double-step shifting effect amplifying the total resonance wavelength shift on the surface by 1.53 - 1.77 times that significantly enhances the sensitivity. We successfully applied this approach to an intact HBV sensing application, which accurately quantified the viral load. This method establishes a new nanoparticle-based sandwiched nanoplasmonic approach to detect and quantify viral load using two-step sensing with broad applications in biosensing.
Yazarlar (10)
1
Fatih Inci
2
Merve Gökşin Karaaslan
3
Amideddin Mataji-Kojouri
4
Pir Ahmad Shah
5
Yeşeren Saylan
6
Yitian Zeng
7
Anirudh Avadhani
8
Robert Sinclair
9
Daryl T.Y. Lau
10
Utkan Demirci
Anahtar Kelimeler
HBV diagnosis
High-throughput assays
Nanoparticles
Nanoplasmonics
Sandwich assays
Kurumlar
Bilkent Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Harvard Medical School
Boston United States
Stanford Engineering
Stanford United States
Stanford University
Stanford United States
Stanford University School of Medicine
Stanford United States
Metrikler
39
Atıf
10
Yazar
5
Anahtar Kelime