Scopus
YÖKSİS Eşleşti
Effects of antiepileptic drugs on ovaries of female Wistar rats
Biotechnic and Histochemistry · Ocak 2022
YÖKSİS Kayıtları
Effects of antiepileptic drugs on ovaries of female Wistar rats
Biotechnic & Histochemistry · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MERVE GÖKŞİN KARAASLAN TUNÇ →
Effects of antiepileptic drugs on ovaries of female Wistar rats
BIOTECHNIC & HISTOCHEMISTRY · 2022 SCI
DOKTOR ÖĞRETİM ÜYESİ MERVE GÖKŞİN KARAASLAN TUNÇ →
Makale Bilgileri
DergiBiotechnic and Histochemistry
Yayın TarihiOcak 2022
Cilt / Sayfa97 · 261-268
Scopus ID2-s2.0-85111013681
Özet
Valproate (VPA) induced changes in ovarian morphology are observed in humans with epilepsy and in non-epileptic animals. The effects of lamotrigine (LTG) on female reproduction is not well known. We investigated whether LTG might be a safer drug for use with patients of reproductive age. Forty Wistar albino female rats were divided into five groups. The control group was injected with saline-vehicle solution. The low dose (LD)-VPA group was injected with 100 mg/kg VPA. The high dose (HD)-VPA group was injected with 500 mg/kg VPA. The LD-LTG group was injected with 10 mg/kg LTG. The HD-LTG group was injected with 50 mg/kg LTG. We evaluated histological and biochemical changes in the ovaries. The number of atretic and cystic follicles was increased in the HD-VPA and HD-LTG groups compared to the control group. A significant increase in malondialdehyde level was found in the VPA groups compared to the control and LTG groups. No significant differences in total glutathione levels or superoxide dismutase activity were found among study groups. Catalase activity was significantly higher in HD-VPA and HD-LTG groups compared to the control, LD-VPA and LD-LTG groups. Prevalence and intensity of caspase-3 immunoreactivity in the luteal cells were significantly greater in the HD-LTG group compared to the control group. VPA administration caused polycystic ovarian syndrome-like changes in the ovary. We found that LD-LTG, which reflects the dose for humans, might be a safer option for use during the reproductive age.
Yazarlar (6)
1
Şeyma Osmanlıoğlu
ORCID: 0000-0003-4963-2685
2
Azibe Yildiz
ORCID: 0000-0001-5686-7867
3
Nigar Vardi
ORCID: 0000-0003-0576-1696
4
Merve Gökşin Karaaslan
5
Onural Ozhan
ORCID: 0000-0001-9018-7849
6
Hakan Parlakpinar
ORCID: 0000-0001-9497-3468
Anahtar Kelimeler
Anti-epileptic drug
lamotrigine
ovary
rat
valproate
Kurumlar
Ankara Medipol University
Ankara Turkey
Inönü Üniversitesi
Malatya Turkey
Inönü Üniversitesi Tip Fakültesi
Malatya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
3
Atıf
6
Yazar
5
Anahtar Kelime