Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Fast Curing Multifunctional Tissue Adhesives of Sericin-Based Polyurethane-Acrylates for Sternal Closure
ACS Applied Materials and Interfaces · Eylül 2022
YÖKSİS Kayıtları
Fast Curing Multifunctional Tissue Adhesives of Sericin-Based Polyurethane-Acrylates for Sternal Closure
ACS APPLIED MATERIALS & INTERFACES · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MERVE GÖKŞİN KARAASLAN TUNÇ →
Makale Bilgileri
DergiACS Applied Materials and Interfaces
Yayın TarihiEylül 2022
Cilt / Sayfa14 · 41819-41833
Scopus ID2-s2.0-85138068459
Erişim🔓 Açık Erişim
Özet
The use of wire cerclage after sternal closure is the standard method because of its rigidity and strength. Despite this, they have many disadvantages such as tissue trauma, operator-induced failures, and the risk of infection. To avoid complications during sternotomy and promote tissue regeneration, tissue adhesives should be used in post-surgical treatment. Here, we report a highly biocompatible, biomimetic, biodegradable, antibacterial, and UV-curable polyurethane-acrylate (PU-A) tissue adhesive for sternal closure as a supportive to wire cerclage. In the study, PU-As were synthesized with variable biocompatible monomers, such as silk sericin, polyethylene glycol, dopamine, and an aliphatic isocyanate 4,4′-methylenebis(cyclohexyl isocyanate). The highest adhesion strength was found to be 4322 kPa, and the ex vivo compressive test result was determined as 715 kPa. The adhesive was determined to be highly biocompatible (on L-929 cells), biodegradable, and antibacterial (on Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus bacteria). Finally, after opening the sternum of rats, the adhesive was applied to bond the bones and cured with UV for 5 min. According to the results, there was no visible inflammation in the adhesive groups, while some animals had high inflammation in the cyanoacrylate and wire cerclage groups. These results indicate that the adhesive may be suitable for sternal fixation by preventing the disadvantages of the steel wires and promoting tissue healing.
Yazarlar (10)
1
Sevgi Balcioglu
ORCID: 0000-0003-0724-4772
2
Samir Abbas Ali Noma
ORCID: 0000-0003-4165-0045
3
Ahmet Ulu
ORCID: 0000-0002-4447-6233
4
Merve Goksin Karaaslan-Tunc
ORCID: 0000-0003-2645-808X
5
Onural Ozhan
ORCID: 0000-0001-9018-7849
6
Suleyman Koytepe
ORCID: 0000-0002-4788-278X
7
Hakan Parlakpinar
ORCID: 0000-0001-9497-3468
8
Nigar Vardi
ORCID: 0000-0003-0576-1696
9
Mehmet Cengiz Colak
ORCID: 0000-0002-0914-4719
10
Burhan Ates
ORCID: 0000-0001-6080-229X
Anahtar Kelimeler
bioadhesives
polyurethane-acrylate
sericin
sternal closure
UV-curable
Kurumlar
Bursa Uludağ Üniversitesi
Bursa Turkey
Inönü Üniversitesi
Malatya Turkey
Inönü Üniversitesi Tip Fakültesi
Malatya Turkey
Sakarya University of Applied Sciences
Serdivan Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
14
Atıf
10
Yazar
5
Anahtar Kelime