Scopus
YÖKSİS DOI Eşleşti
SJR Q2
The relationship between KRAS LCS6 polymorphism and endometrium cancer
Journal of Obstetrics and Gynaecology · Ekim 2020
YÖKSİS Kayıtları
The relationship between KRAS LCS6 polymorphism and endometrium cancer
Journal of Obstetrics and Gynaecology · 2020 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
The relationship between KRAS LCS6 polymorphism and endometrium cancer
Journal of Obstetrics and Gynaecology · 2020 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
The relationship between LCS6 polymorphism and endometrium cancer
Journal of Obstetrics and Gynaecology · 2020 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
The relationship between KRAS LCS6 polymorphism and endometrium cancer
Journal of Obstetrics and Gynaecology · 2019 SCI-Expanded
Öğr. Gör. SÜLEYMAN NERGİZ →
The relationship between KRAS LCS6 polymorphism and endometrium cancer
Journal of Obstetrics and Gynaecology · 2019 SCI-Expanded
Prof. Dr. HASAN ACAR →
The relationship between KRAS LCS6 polymorphism and endometrium cancer
Journal of Obstetrics and Gynaecology · 2019 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
The relationship between KRAS LCS6 polymorphism and endometrium cancer
Journal of Obstetrics and Gynaecology · 2020 SCI-Expanded
Doç. Dr. ERSİN ÇİNTESUN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. AYBİKE PEKİN →
Gum chewing reduces the time to first defaecation after pelvic surgery A randomised controlled study
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Evaluation of cervical involvement in endometrial cancer by transvaginal sonography magnetic resonance imaging and frozen section
2010 ISSN: 0144-3615 SCI-Expanded 4 atıf
Prof. Dr. AYBİKE PEKİN →
Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. SETENAY ARZU YILMAZ →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Expression of cyclin A cyclin E and p27 in normal hyperplastic and frankly malignant endometrial samples
2013 ISSN: 0144-3615 SCI-Expanded 1 atıf
Prof. Dr. AYBİKE PEKİN →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Gum chewing reduces the time to first defaecation after pelvic surgery A randomised controlled study
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment
2014 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Gum chewing reduces the time to first defaecation after pelvic surgery A randomised controlled study
2014 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Expression of cyclin A cyclin E and p27 in normal hyperplastic and frankly malignant endometrial samples
2013 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Management of intra-abdominally translocated contraceptive devices, is surgery the only way to treat this problem?
2017 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Makale Bilgileri
ISSN01443615
Yayın TarihiEkim 2020
Cilt / Sayfa40 · 988-993
Scopus ID2-s2.0-85076108418
Özet
The aim of this study was to investigate the relationship between KRAS LCS6 mutation and endometrial cancer (EC). The study included 105 patients who had hysterectomy for benign reasons and 99 EC patients. The patients with Type 1 EC were classified according to histological properties, cancer stage, grade, tumour dimension, myometrial invasion (MMI), lymphovascular invasion (LVI), cytology, and number of positive lymph nodes. KRAS LCS6 mutation was examined in blood samples taken from all patients in both groups. No statistically significant difference was determined between the EC patients and the control group in demographic features. Weight and the Body Mass Index (BMI) values were higher in EC group (p <.001). While the incidence of this polymorphism is 5.8% throughout the world, the polymorphism rate was found to be 16.2% in the EC group and 12.4% in the control group, with no statistically significant difference determined (p >.05). Despite the higher rate of LCS6 polymorphism incidence in EC patients in this study conducted on a relatively large sample, there was not found to be a statistically significant difference in comparison with the control group. In addition, the presence of LCS6 polymorphism was not determined to have an effect on EC histopathological characteristics.Impact statementWhat is already known on this subject? Endometrial cancer (EC) is a genital system cancer which is one of the most widespread gynecological cancers seen in the USA and other developed countries, In EC, the most frequently seen gene mutations are PTEN tumour suppressor gene, KRAS, β1 catenin, BCL-2, CTNNB and P53 mutations. KRAS LCS6(let-7 miRNA binding region polymorphism) polymorphism has a worldwide incidence of 5.8% (Chin et al. 2008).There are studies shown that KRAS LCS6 polymorphism has an effect on developing EC (Lee et al. 2014), ovarian cancer(Ratner et al. 2010)and endometriosis in women (Grechukhina et al. 2012). What do the results of this study add? In our study, LCS6 located on KRAS 3’-UTR was found at the rate of 16.2% in Type 1 EC patients. This increase is noticeable when it is considered that the incidence of this polymorphism is 5.8% in the general population. The results of the current study supports the preliminary findings of Lee et al. What are the implications of these findings for clinical practice and/or further research? These new genetic markers could help to develop gene-targeted therapies, identify genetic basis of the disease and the factors that could affect the EC prognosis.
Yazarlar (6)
1
Feyza Nur İncesu Çintesun
ORCID: 0000-0003-2131-962X
2
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
3
Ersin Çintesun
ORCID: 0000-0001-8507-5850
4
Süleyman Nergiz
5
Hasan Acar
6
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
endometrium cancer
Genetic
KRAS LCS6
mutation
Kurumlar
Konya Meram Training and Research Hospital
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Obstetrics and Gynaecology
Q2
OA
SJR Skoru0,517
H-Index63
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Obstetrics and Gynecology (Q2)
Metrikler
2
Atıf
6
Yazar
4
Anahtar Kelime