Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Evaluation of cytotoxic, antifungal, and larvicidal activities of different bis-sulfonamide Schiff base compounds
Journal of Biochemical and Molecular Toxicology · Ağustos 2023
YÖKSİS Kayıtları
Evaluation of cytotoxic, antifungal, and larvicidal activities of different bis‐sulfonamide Schiff base compounds
Journal of Biochemical and Molecular Toxicology · 2023 SCI-Expanded
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YÖKSİS Kayıtları — ISSN Eşleşmesi
Effects of bone marrow‐derived mesenchymal stem cells on doxorubicin‐induced liver injury in rats
2022 ISSN: 1095-6670 SCI-Expanded Q2
Doç. Dr. KADRİ MURAT GÜRSES →
Makale Bilgileri
ISSN10956670
Yayın TarihiAğustos 2023
Cilt / Sayfa37
Scopus ID2-s2.0-85157963850
Erişim🔓 Açık Erişim
Özet
Schiff bases (imines or azomethines) are versatile ligands synthesized from the condensation of amino compounds with active carbonyl groups and used for many pharmaceutical and medicinal applications. In our study, we aimed to determine the cytotoxic, antifungal and larvicidal activities of biologically potent bis-sulfonamide Schiff base derivatives that were re-synthesized by us. For this aim, 16 compounds were re-synthesized and tested for their cytotoxic, antifungal and larvicidal properties. Among this series, compounds A1B2, A1B4, A4B2, A4B3, and A4B4 were shown to have cytotoxic activity against tested cancer lung cell line (A549). The most potent antifungal activity was observed in compounds A2B1 and A2B2 against all fungi. A1B1 showed the strongest larvicidal effect at all concentrations at the 72nd h (100% mortality). These obtained results demonstrate that these type of bis-substituted compounds might be used as biologically potent pharmacophores against different types of diseases.
Yazarlar (9)
1
Hasan Aydın
ORCID: 0000-0002-1955-6178
2
Süleyman Akocak
ORCID: 0000-0003-4506-5265
3
Nebih Lolak
ORCID: 0000-0003-0578-2761
4
Önder Yumrutaş
5
Uǧur Uslu
6
Ibrahim Bozgeyik
7
Fatih Üçkardeş
8
Selami Günal
9
Onur Ceylan
Anahtar Kelimeler
antifungal activity
cytotoxicity
larvicidal activity
Schiff base
Kurumlar
Adiyaman Üniversitesi
Adiyaman Turkey
Inönü Üniversitesi
Malatya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Biochemical and Molecular Toxicology
Q2
SJR Skoru0,801
H-Index78
YayıncıJohn Wiley & Sons Inc.
ÜlkeUnited States
Biochemistry (Q2)
Health, Toxicology and Mutagenesis (Q2)
Medicine (miscellaneous) (Q2)
Molecular Medicine (Q2)
Toxicology (Q2)
Molecular Biology (Q3)
Metrikler
6
Atıf
9
Yazar
4
Anahtar Kelime