Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents
Journal of Biochemical and Molecular Toxicology · Ekim 2023
YÖKSİS Kayıtları
In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents
Journal of Biochemical and Molecular Toxicology · 2023 SCI-Expanded
DOÇENT ONUR CEYLAN →
Makale Bilgileri
DergiJournal of Biochemical and Molecular Toxicology
Yayın TarihiEkim 2023
Cilt / Sayfa37
Scopus ID2-s2.0-85165336653
Erişim🔓 Açık Erişim
Özet
Multidrug resistance (MDR) causes difficulties in the treatment of infections and cancer. Research and development studies have become increasingly important for the strategy of preventing MDR. There is a need for new multitarget drug research and advancement to reduce the development of drug resistance in drug-drug interactions and reduce cost and toxic effects. This study aimed to determine the effects of multi-target triazene compounds on antibacterial, antifungal, antiviral, cytotoxic, and larvicidal activities were investigated in vitro. A series of 12 novel of 1,3-diaryltriazene-substituted sulfadiazine (SDZ) derivatives were synthesized, and the obtained pure products characterized in detail by spectroscopic and analytic methods (FT-IR, 1H-NMR, 13C-NMR, and melting points). The antibacterial and antifungal activities of these derivatives (AH1-12) were determined by broth microdilution method. All derivatives have been evaluated in cell-based assays for cytotoxic and antiviral activities against Modified Vaccinia Virus Ankara. The larvicidal efficacy of these chemical compounds was also investigated by using Lucilia sericata (L. sericata) larvae. Twelve 1,3-diaryltriazene-substituted SDZ derivatives (AH1-12) were designed and developed as potent multitargeted compounds. Among them, the AH1 derivative showed the most antibacterial and antifungal activity. Besides, synthesized derivatives AH2, AH3, AH5, and AH7 showed higher antiviral activity than SDZ. All synthesized derivatives showed higher cytotoxic activity than SDZ. Also, they showed larvicidal activity at 72 h of the experiment. As a result, these compounds might be great leads for the development of next-generation multitargeted agents.
Yazarlar (9)
1
Hasan Aydın
ORCID: 0000-0002-1955-6178
2
Süleyman Akocak
ORCID: 0000-0003-4506-5265
3
Nebih Lolak
ORCID: 0000-0003-0578-2761
4
Uǧur Uslu
5
Ahmet Sait
ORCID: 0000-0001-7658-8793
6
Serol Korkmaz
ORCID: 0000-0001-8970-6883
7
Ayşe Parmaksız
ORCID: 0000-0002-2130-0462
8
Onur Ceylan
9
Abdulbaki Aksakal
ORCID: 0000-0002-1622-5111
Anahtar Kelimeler
1,3-diaryl triazenes
antibacterial
antifungal
antiviral activity
sulfa drugs
Kurumlar
Adiyaman Üniversitesi
Adiyaman Turkey
Pendik Veterinary Control Institute
Istanbul Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
9
Yazar
5
Anahtar Kelime