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Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis
Scientific Reports · Aralık 2024
YÖKSİS Kayıtları
Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis
Scientific Reports · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ SÜLEYMAN SERHAT İYİGÜN →
Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis
Scientific Reports · 2024 SCI-Expanded
DOÇENT ONUR CEYLAN →
Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis
Scientific Reports · 2024 SCI-Expanded
PROFESÖR MAHMUT OK →
Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis
Scientific Reports · 2024 SCI-Expanded
DOÇENT AMİR NASERİ →
Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis
Scientific Reports · 2024 SCI-Expanded
DOÇENT MERVE İDER →
Makale Bilgileri
DergiScientific Reports
Yayın TarihiAralık 2024
Cilt / Sayfa14
Scopus ID2-s2.0-85195355801
Erişim🔓 Açık Erişim
Özet
The present study aimed to investigate endothelial glycocalyx (eGCx) damage in cats with feline hemotropic mycoplasmosis caused by Mycoplasma haemofelis using selected biomarkers and to determine the diagnostic and prognostic significance of these biomarkers. The study included 25 cats with feline hemotropic mycoplasmosis and 10 healthy cats. Clinical examination, blood gas analysis, complete blood count, and biochemical analysis were performed. Hemotropic mycoplasmosis diagnosed by microscopic examination and molecularly confirmed by PCR targeting the Mycoplasma haemofelis 16s rRNA gene. To evaluate endothelial glycocalyx damage, syndecan-1, endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA), and vascular endothelial growth factor-A (VEGF-A) concentrations were measured using cat-specific commercial ELISA kits. Of the cats with feline hemotropic mycoplasmosis, 14 (56%) survived and 11 (44%) died. While syndecan-1 and ET-1 concentrations were significantly higher in cats with hemotropic mycoplasmosis compared to the control group (p < 0.001), no statistically significant difference was found for ADMA and VEGF-A concentrations (p > 0.05). Endothelial glycocalyx biomarkers showed significant correlations with each other and with hematological parameters (p < 0.01). The results of the ROC analysis showed that ET-1 with area under the curve (AUC) of 0.821 (p < 0.01) and VEGF-A with AUC of 0.805 (p < 0.010) were found to be significant prognostic indicators. In conclusion, this study demonstrated that serum syndecan-1 and ET-1 can be used as diagnostic and serum ET-1 and VEGF-A as prognostic biomarkers in cats with hemotropic mycoplasmosis. Our results indicate the development of eGCx damage in feline hemotropic mycoplasmosis and suggest that glycocalyx disruption may contribute to the pathogenesis of the disease.
Yazarlar (10)
1
Merve Ider
ORCID: 0000-0003-2928-5452
2
Ceylan Ceylan
3
Amir Naseri
4
Onur Ceylan
5
Murat Kaan Durgut
6
M. Ok
7
Suleyman Serhat Iyigun
8
Busra Burcu Erol
9
Hatice Betul Sahin
10
Merve Cansu Kilickaya
Anahtar Kelimeler
Biomarker
Cat
Endothelin-1
Glycocalyx
Mycoplasma haemofelis
Syndecan-1
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
Metrikler
1
Atıf
10
Yazar
6
Anahtar Kelime