Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Comparison of an estradiol patch and GnRH-antagonist protocol with a letrozole/antagonist protocol for patients without oocyte development, fertilization and/or embryo development in previous IVF cycles
Clinical and Experimental Obstetrics and Gynecology · Ağustos 2021
YÖKSİS Kayıtları
Comparison of an estradiol patch and GnRH-antagonist protocol with a letrozole/antagonist protocol for patients without oocyte development, fertilization and/or embryo development in previous IVF cycles
Clinical and Experimental Obstetrics & Gynecology · 2021 SCI-Expanded
PROFESÖR AYBİKE PEKİN →
Comparison of an estradiol patch and GnRH-antagonist protocol with a letrozole/antagonist protocol for patients without oocyte development, fertilization and/or embryo development in previous IVF cycles
Clinical and Experimental Obstetrics & Gynecology · 2021 SCI-Expanded
PROFESÖR SETENAY ARZU YILMAZ →
Comparison of an estradiol patch and GnRH-antagonist protocol with a letrozole/antagonist protocol for patients without oocyte development, fertilization and/or embryo development in previous IVF cycles
Clinical and Experimental Obstetrics & Gynecology · 2021 SCI-Expanded
DOÇENT ERSİN ÇİNTESUN →
Makale Bilgileri
DergiClinical and Experimental Obstetrics and Gynecology
Yayın TarihiAğustos 2021
Cilt / Sayfa48 · 924-928
Scopus ID2-s2.0-85113522320
Erişim🔓 Açık Erişim
Özet
Background: Diminished ovarian reserve (DOR) is a challenge for clinicians in IVF cycles and several treatment modalities have been suggested to improve outcomes. The aim of this study was to compare live birth rates following ovarian stimulation using a luteal phase estradiol (E2)/gonadotropin releasing hormone (GnRH) antagonist protocol (LPG group) with a letrozole/antagonist (LA group) protocol in patients with DOR. Methods: A total of 51 women with DOR, previously canceled IVF cycles and aged 40 years or less were investigated. In the LPG group (n = 26), a transdermal E2 patch was applied every other day starting 10 days after the luteinizing hormone (LH) surge. At day 11 after the LH surge, GnRH antagonists were administered for three consecutive days. In the LA group (n = 25), letrozole (5 mg/day) treatment was begun on the second day of menstruation and administered for 5 consecutive days. In both groups, gonadotropins were initiated on the second day of menstruation. Results for the two groups were compared using chi-square and Student's t-test, as appropriate. Results: Although the initial and total gonadotropin doses were significantly higher in the LPG group, the peak E2 levels, number of oocytes and fertilization rates and cancellation rates were similar. Trends toward improved live birth rates per transfer (23% vs. 11%) and per cycle (11.5% vs. 4%) were seen in the LPG group compared to the LA group, although the differences were not statistically significant. Discussion: DOR patients with previously canceled IVF cycles may be treated with either the LPG or LA protocols.
Yazarlar (5)
1
Aybike Pekin
2
Ayşe Gül Kebapçilar
3
Ersin Çintesun
ORCID: 0000-0001-8507-5850
4
Setenay Arzu Yilmaz
5
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
Anahtar Kelimeler
Diminished ovarian reserve
Estradiol patch
GnRH-antagonist protocol
Letrozole
Kurumlar
Mersin City Training and Research Hospital
Toroslar Turkey
Selçuk Tip Fakültesi
Konya Turkey