Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Association of Apolipoprotein E Polymorphism with Intravitreal Ranibizumab Treatment Outcomes in Age-Related Macular Degeneration
Current Eye Research · Haziran 2016
YÖKSİS Kayıtları
Association of Apolipoprotein E Polymorphism with Intravitreal Ranibizumab Treatment Outcomes in Age-Related Macular Degeneration
Current Eye Research · 2016 SCI-Expanded
Prof. Dr. NESLİHAN İYİT →
Association of Apolipoprotein E Polymorphism with Intravitreal Ranibizumab Treatment Outcomes in Age-Related Macular Degeneration
Current Eye Research · 2015 SCI-Expanded
Prof. Dr. ŞABAN GÖNÜL →
Association of Apolipoprotein E Polymorphism with Intravitreal Ranibizumab Treatment Outcomes in Age-Related Macular Degeneration
Current Eye Research · 2015 SCI-Expanded
Prof. Dr. ŞABAN GÖNÜL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Characterization of T Lymphocyte subtypes in endotoxin induced uveitis and effect of pentoxifylline treatment
2002 ISSN: 0271-3683 SCI-Expanded 7 atıf
Prof. Dr. ABDULKERİM KASIM BALTACI →
Association of Apolipoprotein E Polymorphism with Intravitreal Ranibizumab Treatment Outcomes in Age-Related Macular Degeneration
2015 ISSN: 0271-3683 SCI-Expanded
Prof. Dr. ŞABAN GÖNÜL →
Association of Apolipoprotein E Polymorphism with Intravitreal Ranibizumab Treatment Outcomes in Age-Related Macular Degeneration
2016 ISSN: 0271-3683 SCI-Expanded
Prof. Dr. NESLİHAN İYİT →
Association of Apolipoprotein E Polymorphism with Intravitreal Ranibizumab Treatment Outcomes in Age-Related Macular Degeneration
2015 ISSN: 0271-3683 SCI-Expanded
Prof. Dr. ŞABAN GÖNÜL →
Novel Zinc Finger Protein Gene 469 (ZNF469) Variants in Advanced Keratoconus
2017 ISSN: 0271-3683 SCI-Expanded Q3
Dr. Öğr. Üyesi ÖZKAN BAĞCI →
In Vivo Confocal Microscopic Evaluation of the Inflammatory Response in Non epithelial Herpes Simplex Keratitis
2012 ISSN: 0271-3683 SCI-Expanded
Prof. Dr. BANU BOZKURT →
Retinal Vascular Changes in Acne Patients Under Isotretinoin Treatment: An Optical Coherence Tomography Angiography Study
2026 ISSN: 0271-3683 SCI-Expanded Q2
Öğr. Gör. SERHAT EKER →
Retinal Vascular Changes in Acne Patients Under Isotretinoin Treatment: An Optical Coherence Tomography Angiography Study
2025 ISSN: 0271-3683 SCI-Expanded Q2
Doç. Dr. FATMA TUNÇEZ AKYÜREK →
Makale Bilgileri
Dergi
Current Eye Research
ISSN02713683
Yayın TarihiHaziran 2016
Cilt / Sayfa41 · 862-866
Scopus ID2-s2.0-84945242214
Özet
Purpose: Genetic factors are known to influence the response to anti-vascular endothelial growth factor (VEGF) treatment in exudative age-related macular degeneration (AMD). The current study was conducted to investigate the association of Apolipoprotein E (ApoE) polymorphism with the treatment response to ranibizumab for exudative AMD. Methods: One hundred nine eyes (109 patients, 59.6% male, mean age 63.84 ± 7.22 years) treated with intravitreal ranibizumab injections were included in the analysis. Smoking status and lesion type were recorded. Patients were categorized into three groups according to visual acuity (VA) change at 6 months after the first injection: VA loss >5 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (Group 1); VA change between five ETDRS letters gain and loss (Group 2); VA improvement >5 ETDRS letters (Group 3). The association of ApoE gene polymorphisms with the three groups was evaluated. Results: Both smoking status and lesion type showed no significant association with VA change (p = 0.12 and p = 0.64, respectively). A lower frequency of ɛ2 and a higher frequency of ɛ4 were observed in Group 3 (2.9 and 25.7%, respectively). VA improvement with more than five ETDRS letters was significantly associated with the presence of the ɛ4 genotype (p = 0.01). Conclusions: This study demonstrated that carriers of the ApoE ɛ4 polymorphism genotype show demonstrable improvement in VA after treatment with ranibizumab in exudative AMD. ApoE polymorphism identification may be used as a genetic screening to tailor individualized therapeutic approach for optimal treatment in neovascular AMD.
Yazarlar (7)
1
Berker Bakbak
2
Banu Turgut Ozturk
ORCID: 0000-0003-0702-6951
3
A. Zamani
4
Şaban Gönül
5
Neslihan Iyit
6
Şansal Gedik
7
M. S. Yildirim
Anahtar Kelimeler
Age-related macular degeneration
ApoE
Apolipoprotein E
ranibizumab
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Current Eye Research
Q2
SJR Skoru0,685
H-Index98
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Ophthalmology (Q2)
Sensory Systems (Q2)
Cellular and Molecular Neuroscience (Q3)
Metrikler
9
Atıf
7
Yazar
4
Anahtar Kelime