Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Serum sclerostin level and its relation to subclinical atherosclerosis in the polycystic ovary syndrome phenotypes: A prospective controlled study
Turkish Journal of Obstetrics and Gynecology · Eylül 2021
YÖKSİS Kayıtları
Serum sclerostin level and its relation to subclinical atherosclerosis in the polycystic ovary syndrome phenotypes: A prospective controlled study
Journal of Turkish Society of Obstetric and Gynecology · 2021 PubMed, PubMed Central (PMC), Web of Science-Emerging Sources Citation Index (ESCI), EBSCO, Embase, ProQuest, British Library, Gale, Index Copernicus, CINAHL, Tübitak/Ulakbim Turkish Medical Database, Turk Medline, J-Gate, IdealOnline, Hinari, GOALI, ARDI, OARE, AGORA and Turkiye Citation Index
DOÇENT ERSİN ÇİNTESUN →
Makale Bilgileri
DergiTurkish Journal of Obstetrics and Gynecology
Yayın TarihiEylül 2021
Cilt / Sayfa18 · 167-174
Scopus ID2-s2.0-85118356521
Erişim🔓 Açık Erişim
Özet
Objective: We aim to study the relationship between atherosclerosis and serum sclerostin levels in different phenotypes of polycystic ovary syndrome (PCOS). Materials and Methods: A total of 134 women with PCOS and 33 age-matched controls participated in this study. Women with PCOS were further divided into subgroups based on their PCOS phenotypes: phenotype A (n=35), phenotype B (n=33), phenotype C (n=31), and phenotype D (n=35). Metabolic parameters, hormonal parameters, carotid intima-media thickness (CIMT), and sclerostin levels were compared among the PCOS phenotypes. Results: Statistically significant differences occurred among groups regarding follicle-stimulating hormone, luteinizing hormone, estradiol, total cholesterol, low-density lipoprotein, Ferriman-Gallwey score, total testosterone, and free androgen index. The mean CIMT was statistically higher in all PCOS phenotypes than in controls. In subgroup comparison, phenotypes A and B had a higher body mass index (BMI) adjusted CIMT than other phenotypes, respectively (p=0.005). Serum sclerostin levels were higher in PCOS patients than in controls. A concentration of ≥6.297 ng/mL showed a sensitivity of 56% and a specificity of 69.7% to predict PCOS. The BMI-adjusted sclerostin level was significantly higher in phenotype C (20.3±0.7 ng/mL) than in other phenotypes. Conclusion: Patients with phenotypes A and B seem to have an increased risk for atherosclerosis. Although sclerostin was higher in PCOS patients, we could not demonstrate the relation between sclerostin and atherosclerosis in different PCOS phenotypes.
Yazarlar (6)
1
Feyza Nur İncesu Çintesun
ORCID: 0000-0003-2131-962X
2
Ümmügülsüm Can
3
Ersin Çintesun
ORCID: 0000-0001-8507-5850
4
Ayşegül Altunkeser
5
Aybike Kaya
6
Oğuzhan Günenç
Anahtar Kelimeler
Atherosclerosis
Carotid intima-media thickness
Polycystic ovary syndrome
Sclerostin
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
1
Atıf
6
Yazar
4
Anahtar Kelime