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The potential of microarray databases to identify tissue specific genes

Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2016

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YÖKSİS Kayıtları
The potential of microarray databases to identify tissue specific genes
Journal of the Faculty of Veterinary Medicine, Kafkas University · 2015 SCI-Expanded
Prof. Dr. HİLAL ARIKOĞLU →
Mikroarray Veritabanlarının Doku Spesifik Genlerin Belirlenmesindeki Potansiyeli
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2016 SCI-Expanded
Prof. Dr. SAİM BOZTEPE →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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Bir Ceylanda Gazella gazella Generalize Reaktif Amiloidoz Olgusu
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Fatty Acid Composition and Conjugated Linoleic Acid CLA Content of Some Commercial Milk in Turkey
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The potential of microarray databases to identify tissue specific genes
2015 ISSN: 1300-6045 SCI-Expanded
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Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
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Makale Bilgileri

ISSN13006045
Yayın TarihiOcak 2016
Cilt / Sayfa22 · 29-35
Özet Tissue specific genes play important roles in development and metabolism. Currently, GenBank has 3363628 GEO Profiles and 397988 microarray data related to various tissues. To evaluate the huge amounts of data and identify tissue specific genes, it is necessary to develop and use new strategies. To that end, this study discusses if microarray and microarray related GEO Profiles are a useful tool to identify new tissue specific genes. In the current study, adipose tissue sellected as a target tissue in order to find new tissue specific genes. Therefore, the human and mouse microarray data were analyzed comparatively. To support the microarray data, adipose tissue related GEO Profiles were selected from PubMed. Subsequently, adipose tissue related microarray and GEO Profiles were analysed simultaneously. According to analysis of microarray and GEO Profiles, Chrdl1 (Chordin-like 1) gene was hypothesized as a novel adipose specific gene. In order to test the hypothesis, RT-PCR analysis were performed for the bovine tissue distribution. As a result, the hypothesis was successfully tested and Chrdl1 gene was found highly specific in bovine adipose tissue than in various other tissues. Thus, it is concluded that microarray and microarray related GEO Profiles are a useful tool to identify new tissue specific genes.

Yazarlar (3)

1
Selçuk Kaplan
2
S. Boztepe
3
Hilal Arikoglu
ORCID: 0000-0002-6600-6603

Anahtar Kelimeler

Adipose specific gene Adipose tissue Chordin-like 1 Microarray

Kurumlar

Selçuk Üniversitesi
Selçuklu Turkey
Tekirdağ Namık Kemal Üniversitesi
Tekirdag Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3 OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)
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Metrikler

4
Atıf
3
Yazar
4
Anahtar Kelime

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