Scopus
YÖKSİS Eşleşti
The potential of microarray databases to identify tissue specific genes
Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2016
YÖKSİS Kayıtları
The potential of microarray databases to identify tissue specific genes
Journal of the Faculty of Veterinary Medicine, Kafkas University · 2015 SCI-Expanded
PROFESÖR HİLAL ARIKOĞLU →
Mikroarray Veritabanlarının Doku Spesifik Genlerin Belirlenmesindeki Potansiyeli
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2016 SCI-Expanded
PROFESÖR SAİM BOZTEPE →
Makale Bilgileri
DergiKafkas Universitesi Veteriner Fakultesi Dergisi
Yayın TarihiOcak 2016
Cilt / Sayfa22 · 29-35
Scopus ID2-s2.0-84946599992
Özet
Tissue specific genes play important roles in development and metabolism. Currently, GenBank has 3363628 GEO Profiles and 397988 microarray data related to various tissues. To evaluate the huge amounts of data and identify tissue specific genes, it is necessary to develop and use new strategies. To that end, this study discusses if microarray and microarray related GEO Profiles are a useful tool to identify new tissue specific genes. In the current study, adipose tissue sellected as a target tissue in order to find new tissue specific genes. Therefore, the human and mouse microarray data were analyzed comparatively. To support the microarray data, adipose tissue related GEO Profiles were selected from PubMed. Subsequently, adipose tissue related microarray and GEO Profiles were analysed simultaneously. According to analysis of microarray and GEO Profiles, Chrdl1 (Chordin-like 1) gene was hypothesized as a novel adipose specific gene. In order to test the hypothesis, RT-PCR analysis were performed for the bovine tissue distribution. As a result, the hypothesis was successfully tested and Chrdl1 gene was found highly specific in bovine adipose tissue than in various other tissues. Thus, it is concluded that microarray and microarray related GEO Profiles are a useful tool to identify new tissue specific genes.
Yazarlar (3)
1
Selçuk Kaplan
2
S. Boztepe
3
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
Anahtar Kelimeler
Adipose specific gene
Adipose tissue
Chordin-like 1
Microarray
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Tekirdağ Namık Kemal Üniversitesi
Tekirdag Turkey
Metrikler
4
Atıf
3
Yazar
4
Anahtar Kelime