Scopus
YÖKSİS Eşleşti
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
Toxicology Mechanisms and Methods · Ocak 2024
YÖKSİS Kayıtları
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
Toxicology Mechanisms and Methods · 2024 SCI-Expanded
PROFESÖR MEHMET TUZCU →
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
Toxicology Mechanisms and Methods · 2024 SCI-Expanded
PROFESÖR ÖZGÜR ÖZDEMİR →
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
Toxicology Mechanisms and Methods · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ ZEYNEP ÇELİK KENAR →
Makale Bilgileri
DergiToxicology Mechanisms and Methods
Yayın TarihiOcak 2024
Cilt / Sayfa34 · 413-422
Scopus ID2-s2.0-85180830477
Özet
Gentamicin, an aminoglycoside antibiotic, is nowadays widely used in the treatment of gram-negative microorganisms. The antimicrobial, anti-inflammatory, and antioxidant activities of eucalyptol, a type of saturated monoterpene, have been reported in many studies. The aim of this study was to examine the possible effects of eucalyptol on gentamicin-induced renal toxicity. A total of 32 rats were divided into 4 groups; Control (C), Eucalyptol (EUC), Gentamicin (GEN), and Gentamicin + Eucalyptol (GEN + EUC). In order to induce renal toxicity, 100 mg/kg gentamicin was administered intraperitoneally (i.p.) for 10 consecutive days in the GEN and GEN + EUC groups. EUC and GEN + EUC groups were given 100 mg/kg orally of eucalyptol for 10 consecutive days. Afterwards, rats were euthanized and samples were taken and subjected to histopathological, biochemical, immunohistochemical, and real-time PCR examinations. The blood urea nitrogen (BUN) and creatinine (CRE) levels were significantly decreased in the GEN + EUC group (0.76 and 0.69-fold, respectively) compared to the GEN group. The glutathione peroxidase (GPx) and catalase (CAT) activities were significantly increased in the GEN + EUC group (1.35 and 2.67-fold, respectively) compared to the GEN group. In GEN group, Nuclear factor kappa B (NF-kB), Interleukin 1-beta (IL-1β), Inducible nitric oxide synthase (iNOS), Tumor necrosis factor-α (TNF-α), Caspase-3, 8-Hydroxy-2′-deoxyguanosine (8-OHdG) and Nuclear factor erythroid 2–related factor (Nrf2) expression levels were found to be quite irregular. GEN + EUC group decreased the expressions of NF-kB, IL-1β, iNOS, TNF-α, Caspase-3, and 8-OHdG (0.55, 0.67, 0.54, 0.54, 0.63 and 0.67-fold, respectively), while it caused increased expression of Nrf2 (3.1 fold). In addition, eucalyptol treatment ameliorated the histopathological changes that occurred with gentamicin. The results of our study show that eucalyptol has anti-inflammatory, antioxidative, antiapoptotic, nephroprotective, and curative effects on gentamicin-induced nephrotoxicity.
Yazarlar (10)
1
G. Akcakavak
2
Filiz Kazak
ORCID: 0000-0002-9065-394X
3
Ozhan Karatas
4
Halil Alakus
ORCID: 0000-0001-9265-2310
5
Ibrahim Alakus
ORCID: 0000-0002-2031-7035
6
Omer Kirgiz
7
Zeynep Celik
ORCID: 0000-0002-9667-5728
8
Mehmet Zeki Yilmaz Deveci
9
O. Ozdemir
10
Mehmet Tuzcu
Anahtar Kelimeler
apoptosis
eucalyptol
Gentamicin
inflammation
nephrotoxicity
oxidative stress
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
10
Yazar
6
Anahtar Kelime