Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
Toxicology Mechanisms and Methods · Ocak 2024
YÖKSİS Kayıtları
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
Toxicology Mechanisms and Methods · 2024 SCI-Expanded
Prof. Dr. MEHMET TUZCU →
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
Toxicology Mechanisms and Methods · 2024 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
Toxicology Mechanisms and Methods · 2024 SCI-Expanded
Arş. Gör. ZEYNEP ÇELİK KENAR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty
2016 ISSN: 1537-6516 SCI-Expanded
Dr. Öğr. Üyesi ALİ AŞCI →
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
2024 ISSN: 1537-6516 SCI-Expanded Q2
Arş. Gör. ZEYNEP ÇELİK KENAR →
Investigation of the effects of Theranekron and Sorafenib treatments on carcinogenesis, apoptosis and biochemical profile in hepatocellular carcinoma in rats
2024 ISSN: 1537-6516 SCI Q2
Prof. Dr. FİRUZE KURTOĞLU →
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
2024 ISSN: 1537-6516 SCI-Expanded Q2
Prof. Dr. MEHMET TUZCU →
Investigation of the effects of Theranekron and Sorafenib treatments on carcinogenesis, apoptosis and biochemical profile in hepatocellular carcinoma in rats.
2024 ISSN: 1537-6516 SCI-Expanded Q2
Dr. Öğr. Üyesi BEYZA SUVARIKLI ALAN →
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis
2024 ISSN: 1537-6516 SCI-Expanded Q2
Prof. Dr. ÖZGÜR ÖZDEMİR →
Investigation of the effects of Theranekron and Sorafenib treatments on carcinogenesis, apoptosis and biochemical profile in hepatocellular carcinoma in rats
2024 ISSN: 1537-6516 SCI-Expanded Q2
Prof. Dr. ÖZGÜR ÖZDEMİR →
Makale Bilgileri
ISSN15376516
Yayın TarihiOcak 2024
Cilt / Sayfa34 · 413-422
Scopus ID2-s2.0-85180830477
Özet
Gentamicin, an aminoglycoside antibiotic, is nowadays widely used in the treatment of gram-negative microorganisms. The antimicrobial, anti-inflammatory, and antioxidant activities of eucalyptol, a type of saturated monoterpene, have been reported in many studies. The aim of this study was to examine the possible effects of eucalyptol on gentamicin-induced renal toxicity. A total of 32 rats were divided into 4 groups; Control (C), Eucalyptol (EUC), Gentamicin (GEN), and Gentamicin + Eucalyptol (GEN + EUC). In order to induce renal toxicity, 100 mg/kg gentamicin was administered intraperitoneally (i.p.) for 10 consecutive days in the GEN and GEN + EUC groups. EUC and GEN + EUC groups were given 100 mg/kg orally of eucalyptol for 10 consecutive days. Afterwards, rats were euthanized and samples were taken and subjected to histopathological, biochemical, immunohistochemical, and real-time PCR examinations. The blood urea nitrogen (BUN) and creatinine (CRE) levels were significantly decreased in the GEN + EUC group (0.76 and 0.69-fold, respectively) compared to the GEN group. The glutathione peroxidase (GPx) and catalase (CAT) activities were significantly increased in the GEN + EUC group (1.35 and 2.67-fold, respectively) compared to the GEN group. In GEN group, Nuclear factor kappa B (NF-kB), Interleukin 1-beta (IL-1β), Inducible nitric oxide synthase (iNOS), Tumor necrosis factor-α (TNF-α), Caspase-3, 8-Hydroxy-2′-deoxyguanosine (8-OHdG) and Nuclear factor erythroid 2–related factor (Nrf2) expression levels were found to be quite irregular. GEN + EUC group decreased the expressions of NF-kB, IL-1β, iNOS, TNF-α, Caspase-3, and 8-OHdG (0.55, 0.67, 0.54, 0.54, 0.63 and 0.67-fold, respectively), while it caused increased expression of Nrf2 (3.1 fold). In addition, eucalyptol treatment ameliorated the histopathological changes that occurred with gentamicin. The results of our study show that eucalyptol has anti-inflammatory, antioxidative, antiapoptotic, nephroprotective, and curative effects on gentamicin-induced nephrotoxicity.
Yazarlar (10)
1
G. Akcakavak
2
Filiz Kazak
ORCID: 0000-0002-9065-394X
3
Ozhan Karatas
4
Halil Alakus
ORCID: 0000-0001-9265-2310
5
Ibrahim Alakus
ORCID: 0000-0002-2031-7035
6
Omer Kirgiz
7
Zeynep Celik
ORCID: 0000-0002-9667-5728
8
Mehmet Zeki Yilmaz Deveci
9
O. Ozdemir
10
Mehmet Tuzcu
Anahtar Kelimeler
apoptosis
eucalyptol
Gentamicin
inflammation
nephrotoxicity
oxidative stress
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Toxicology Mechanisms and Methods
Q3
SJR Skoru0,636
H-Index62
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Health, Toxicology and Mutagenesis (Q3)
Toxicology (Q3)
Metrikler
31
Atıf
10
Yazar
6
Anahtar Kelime