Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Tarantula cubensis alcohol extract enhances the tumoricidal effect of capecitabine via multiple pathways in azoxymethane-induced colorectal cancer in rats
Tropical Journal of Pharmaceutical Research · Şubat 2024
YÖKSİS Kayıtları
Tarantula cubensis alcoholic extract enhances the tumoricidal effect of capecitabine via multiple pathways in azoxymethane-induced colorectal cancer in rats
Tropical Journal of Pharmaceutical Research · 2024 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
Tarantula cubensis alcoholic extract enhances the tumoricidal effect of capecitabine via multiple pathways in azoxymethane-induced colorectal cancer in rats
Tropical Journal of Pharmaceutical Research · 2024 SCI-Expanded
Prof. Dr. MEHMET TUZCU →
Tarantula cubensis alcoholic extract enhances the tumoricidal effect of capecitabine via multiple pathways in azoxymethane-induced colorectal cancer in rats
Tropical Journal of Pharmaceutical Research · 2024 Scopus
Arş. Gör. ZEYNEP ÇELİK KENAR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effects of herbal-based toothpastes on cell viability
2022 ISSN: 1596-5996 SCI-Expanded Q3
Doç. Dr. FİRDEVS KAHVECİOĞLU →
Effects of herbal-based toothpastes on cell viability
2022 ISSN: 1596-5996 SCI-Expanded Q3
Prof. Dr. HAYRİYE ESRA ÜLKER →
Effect of high fructose consumption on plasma levels of leptin, adropin and insulin, and serum biochemical parameters in mature adult rats
2022 ISSN: 1596-5996 SCI-Expanded Q4
Prof. Dr. SEYFULLAH HALİLOĞLU →
Tarantula cubensis alcoholic extract enhances the tumoricidal effect of capecitabine via multiple pathways in azoxymethane-induced colorectal cancer in rats
2024 ISSN: 1596-5996 Scopus
Arş. Gör. ZEYNEP ÇELİK KENAR →
Tarantula cubensis alcoholic extract enhances the tumoricidal effect of capecitabine via multiple pathways in azoxymethane-induced colorectal cancer in rats
2024 ISSN: 1596-5996 SCI-Expanded Q4
Prof. Dr. ÖZGÜR ÖZDEMİR →
Makale Bilgileri
ISSN15965996
Yayın TarihiŞubat 2024
Cilt / Sayfa23 · 291-297
Scopus ID2-s2.0-85188745206
Erişim🔓 Açık Erişim
Özet
Purpose: To evaluate the effect of a combination of Tarantula cubensis alcohol extract (TCAE) and capecitabine (CAP) in the treatment of azoxymethane (AOM)-induced colorectal cancer (CRC). Methods: Forty-two Wistar albino rats were divided into 7 groups with 6 rats in each group. The groups consisted of Control (C), Control+TCAE (C-TCAE), Control+CAP (C-CAP), Cancer control (CC), Cancer+TCAE (CC-TCAE), Cancer+CAP (CC-CAP) and Cancer+CAP+TCAE (CC-CAP+TCAE). To induce CRC, AOM (15 mg/kg) was administered to rats subcutaneously (sc) twice at a one-week interval to all the groups except control. From the 15th week, TCAE (0.2 mL/rat sc) was administered to CC-TCAE group every 3 days for 4 weeks, and CAP (40 mg/kg/day) was administered by gavage to CC-CAP group for 4 weeks. In CC-CAP+TCAE group, TCAE (0.2 mL/rat sc) was administered every 3 days for 4 weeks, and CAP (40 mg/kg/day) was administered gavage for 4 weeks. Animals were treated for 18 weeks. Aberrant crypt foci (ACF) were evaluated histopathologically among CC, CC-TCAE, CC-CAP, and CC-CAP+TCAE groups. β-catenin, CD15, Proliferating Cell Nuclear Antigen (PCNA), and Nuclear Factor kappa B (NF-κB) expression levels were immunohistochemically compared among all groups. Results: Histopathologically, ACF scores were significantly increased in CC group, while a significant decrease in the relevant scores (p < 0.001) was observed in CC-CAP and CC-CAP+TCAE treatment groups, and the lowest scores were in CC-CAP+TCAE group. Immunohistochemically, in CC group, β-catenin, Nuclear Factor kappa B (NF-κB), Proliferating Cell Nuclear Antigen (PCNA) and CD15 expressions were highly irregular. CC-CAP and CC-CAP+TCAE groups had significantly reduced expressions (p < 0.001), and the lowest expressions were in CC-CAP+TCAE group. Conclusion: The combined use of TCAE and CAP in treatment of CRC has a synergistic effect and increases the anticancer efficacy of TCAE, and CAP. More studies at the molecular level are needed in the future to demonstrate the clinical benefit of TCAE supplementation during the treatment of CRC with CAP.
Yazarlar (6)
1
G. Akcakavak
2
Zeynep Celik
ORCID: 0000-0002-9667-5728
3
Ozhan Karatas
4
Osman Dogan
5
O. Ozdemir
6
Mehmet Tuzcu
Anahtar Kelimeler
Azoxymethane
CD15
Colorectal cancer
NF-κB
PCNA
β-catenin
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Tropical Journal of Pharmaceutical Research
Q4
OA
SJR Skoru0,165
H-Index56
YayıncıUniversity of Benin
ÜlkeNigeria
Pharmaceutical Science (Q4)
Pharmacology (medical) (Q4)
Metrikler
4
Atıf
6
Yazar
6
Anahtar Kelime