Scopus
YÖKSİS Eşleşti
Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation
Journal of Drug Delivery Science and Technology · Ekim 2024
YÖKSİS Kayıtları
Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation
Journal of Drug Delivery Science and Technology · 2024 SCI-Expanded
PROFESÖR MEHMET TUZCU →
Makale Bilgileri
DergiJournal of Drug Delivery Science and Technology
Yayın TarihiEkim 2024
Cilt / Sayfa100
Scopus ID2-s2.0-85202784685
Özet
Incisional hernia, a prevalent postoperative complication, is characterized by the protrusion of organs or tissues through damaged abdominal wall. Predisposing factors for hernias include obesity, wound infections, immunosuppression, and comorbidities. However, hernia patches currently in use, including the commercial polypropylene (PP) patch, still have limitations in providing the mechanical and biological properties necessary for abdominal wall regeneration. In this study, three dimensional (3D) printing and coaxial electrospinning methods were combined to create a multifunctional double layered hernia repair biopatch to overcome these limitations. The double-layer design of the biopatch serves a multifunctional role in addressing incisional hernia models, with 3D printed ciprofloxacin (CIP) loaded polycaprolactone (PCL)/gelatin (Ge) scaffold (3DCIP) layer and coaxially electrospun PCL/Ge/κ-carrageenan (κ-C) nanofiber (NF) layers. While 3DCIP layers provides temporary mechanical reinforcement to the damaged abdominal wall, prevention of adhesions to internal organs, and reduction of surgical site infections, NF layer serves as tissue regeneration and fast wound healing. The developed multifunctional hernia biopatches underwent comprehensive physical and chemical characterization, followed by in vitro and in vivo evaluations. These evaluations included comparisons with a commercial PP patch, which was used as the control in the experiments. The study successfully fabricated multifunctional hernia biopatches with excellent antibacterial properties, high mechanical robustness, and strong biocompatibility.
Yazarlar (17)
1
Mehmet Zeki Yilmaz Deveci
ORCID: 0000-0002-9532-247X
2
Gozde Enguven
ORCID: 0009-0008-6096-3470
3
Hasan Ege
4
Ibrahim Alakus
ORCID: 0000-0002-2031-7035
5
Gokhan Agturk
6
Fulya Dal Yontem
ORCID: 0000-0003-4767-083X
7
Senanur Yilmaz
8
Omer Kirgiz
9
G. Akcakavak
10
Filiz Kazak
ORCID: 0000-0002-9065-394X
11
Burak Aksu
12
Halil Alakus
ORCID: 0000-0001-9265-2310
13
Cafer Tayer Isler
ORCID: 0000-0002-1910-8316
14
Mehmet Tuzcu
15
Muhammed Enes Altug
16
Oguzhan Gunduz
17
Zeynep Ruya Ege
ORCID: 0009-0005-5725-7768
Anahtar Kelimeler
3D printing
Biopatch
Ciprofloxacin
Controlled release
Electrospinning
Hernia repair
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Haliç Üniversitesi
Istanbul Turkey
İstanbul Arel Üniversitesi
Istanbul Turkey
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Istanbul Turkey
Koç Üniversitesi
Istanbul Turkey
Marmara Üniversitesi
Istanbul Turkey
Marmara Üniversitesi Tip Fakültesi
Istanbul Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey