Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Strontium chloride: Can it be a new treatment option for ulcerative colitis?
BioMed Research International · Ocak 2014
YÖKSİS Kayıtları
Strontium Chloride: Can It Be a New Treatment Option for Ulcerative Colitis?
Hindawi Limited · 2014 SCI-Expanded
PROFESÖR MEHMET TUZCU →
Makale Bilgileri
DergiBioMed Research International
Yayın TarihiOcak 2014
Cilt / Sayfa2014
Scopus ID2-s2.0-84904101659
Erişim🔓 Açık Erişim
Özet
Background/Aims. Patients with ulcerative colitis still need effective therapy without major side effects. It has been found that strontium can suppress NFκB activation induced by TNF-α. This opens a gate to a new anti-TNF agent which is cheap and can be given orally. We for the first time aimed to investigate the effect of strontium chloride (SrCl on inflammation in experimental colitis. Methods. Thirty female Wistar albino rats were divided into 5 groups each containing 6 rats. The rats in groups 1 and 2 served as the healthy control and colitis group, respectively. The rats in groups 3, 4, and 5 had colitis and received 40 mg/kg SrCl 160 mg/kg SrCl<2<, and 1 mg/kg prednisolone by oral gavage, respectively. The rats were sacrificed for histological evaluation and determination of serum neopterin, TNF-α, and IFN-γ levels. Results. The neopterin, TNF-α and IFNγ levels of group 2 was significantly higher than the other groups. The neopterin, TNF-α, and IFN-γ levels of controls and other treatment groups were comparable. There were a significant difference in macroscopic and microscopic healing between group 2 and other groups histologically. But there was not a significant difference within treatment receiving groups. Conclusion. SrClhad comparable therapeutic efficiency with prednisolone. © 2014 Firdevs Topal et al.
Yazarlar (6)
1
Firdevs Topal
2
Ozlem Yonem
3
Nevin Tuzcu
ORCID: 0000-0001-5899-3955
4
Mehmet Tuzcu
5
Hilmi Ataseven
6
Melih Akyol
Kurumlar
Anadolu Hospital
Sivas Turkey
Ataturk Training and Research Hospital
Izmir Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Metrikler
9
Atıf
6
Yazar