Scopus
Evaluation of serum perforin, caspase-3, sFasL and M-30 levels as apoptotic markers in children with crimean-congo hemorrhagic fever
Journal of Pediatric Infectious Diseases · Ocak 2015
Makale Bilgileri
DergiJournal of Pediatric Infectious Diseases
Yayın TarihiOcak 2015
Cilt / Sayfa34 · 208-213
Scopus ID2-s2.0-84925390202
Özet
Background: Apoptosis is a main regulator in responses of cellular immunity throughout systemic viral infections. Perforin, soluble Fas ligand, caspase-3 and caspase-cleaved cytokeratin-18 (M-30) are mediators of apoptosis. The aim of this study is the evaluation of Crimean-Congo hemorrhagic fever (CCHF) disease changes in the levels of these apoptotic markers and the relation of these changes with disease severity. Methods: Forty-nine hospitalized children with CCHF and 36 healthy controls were enrolled in this prospective study. The CCHF patients were classified into 2 groups based on disease severity (severe group and nonsevere group). Demographic characteristics and clinical and laboratory findings of all patients were recorded on admission. Results: Serum perforin, caspase-3 and soluble Fas ligand levels were found to be significantly higher both in the severe and nonsevere CCHF groups than the healthy control group (P < 0.05), but there was no significant difference in these apoptotic markers between severe and nonsevere CCHF groups (P > 0.05). In addition, serum M-30 levels did not differ significantly among all groups (P > 0.05). There was a positive correlation between serum values for perforin, caspase-3 and M-30 and the disease's severity criteria such as aspartate aminotransferase and/or alanine aminotransferase. The serum levels of all these markers were negatively correlated with disease severity criteria such as the platelet count. Conclusions: In this study, we concluded that the interactions of cytolytic granules containing perforin and caspase cascade and Fas-FasL may play an important role in the pathogenesis of CCHF in children.
Yazarlar (11)
1
A. S. Güven
2
Enver Sancakdar
3
Elif B. Uysal
4
A. Kaya
5
Mehmet B. Oflaz
6
Hekim Karapınar
7
Fatih Bolat
8
Nevin Tuzcu
ORCID: 0000-0001-5899-3955
9
Köksal Deveci
10
Ömer Cevit
11
Füsun D. Icagasioglu
Anahtar Kelimeler
Apoptosis
Caspase-3
Children
Crimean-Congo hemorrhagic fever
M-30
Perforin
Soluble Fas ligand
Kurumlar
Cumhuriyet Üniversitesi
Sivas Turkey
Cumhuriyet Üniversitesi Tip Fakültesi
Sivas Turkey
Metrikler
12
Atıf
11
Yazar
7
Anahtar Kelime