Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Determination of Apoptosis, Necroptosis and Autophagy Markers by Real-time PCR in Naturally Infected Pneumonic Pasteurellosis caused by Pasteurella multocida and Mannheimia haemolytica in Cattle
Pakistan Veterinary Journal · Ocak 2024
YÖKSİS Kayıtları
Determination of Apoptosis, Necroptosis and Autophagy Markers by Real-time PCR in Naturally Infected Pneumonic Pasteurellosis caused by Pasteurella multocida and Mannheimia haemolytica in Cattle
PAKISTAN VETERINARY JOURNAL · 2024 SCI-Expanded
Prof. Dr. MEHMET TUZCU →
Determination of Apoptosis, Necroptosis and Autophagy Markers by Real-time PCR in Naturally Infected Pneumonic Pasteurellosis caused by Pasteurella multocida and Mannheimia haemolytica in Cattle
PAKISTAN VETERINARY JOURNAL · 2024 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Clinical Comparison of Medetomidine with Isoflurane or Sevoflurane for Anesthesia in Horses
2015 ISSN: 0253-8318 SSCI
Prof. Dr. MUSTAFA ARICAN →
Bacillus anthracis isolated from a dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
A Retrospective Study of Fractures in Neonatal Calves 181 Cases 2002 2012
2013 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. KURTULUŞ PARLAK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. IRMAK DİK →
The investigation of bovine viral diarrhoea virus antigens with immunofluorescence and immunohistochemical methods in bovine abortions
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of different storage temperatures on the stability of bovine viral diarrhea virus RNA in blood samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ATİLLA ŞİMŞEK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. SİBEL YAVRU →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. OSMAN ERGANİŞ →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and PetDogs
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. UÇKUN SAİT UÇAN →
Quantification of mitral regurgitation in Anatolian Shepherd Dogs with aseymtomatic degenerative mitral valve disease
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HASAN GÜZELBEKTEŞ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and Pet Dogs
2016 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
In Vitro Activity of Toxin Binders on Aflatoxin B1 in Poultry Gastrointestinal Medium
2018 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling
and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. MUSTAFA ORHUN DAYAN →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q1
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Makale Bilgileri
ISSN02538318
Yayın TarihiOcak 2024
Cilt / Sayfa44 · 483-489
Scopus ID2-s2.0-85198609257
Erişim🔓 Açık Erişim
Özet
Pneumonic pasteurellosis (PP) is defined as one of the pivotal infectious diseases caused by Pasteurella multocida and Mannheimia haemolytica. This study aimed to determine the levels of Bcl-2-associated protein X (Bax), B-cell lymphoma 2 (Bcl-2), caspase-3, autophagy related-5 (Atg5), beclin-1 and receptor interacting protein-3 (RIP3) in lung tissues with naturally infected PP caused by P. multocida and M. haemolytica, and to reveal their effects on the pathogenesis of P. multocida and M. haemolytica pneumonia. The material of the study consisted of 150 fibrinous pneumonia/pleuropneumonia and 10 healthy lung tissue samples. Relevant samples were examined by histopathological, immunohistochemical and real-time PCR methods. Immunohistochemically, 23 (15.3%) were positive for P. multocida, and 17 (11.3%) were positive for M. haemolytica. Subsequently, the processes of apoptosis, autophagy and necroptosis for P. multocida and M. haemolytica were evaluated by real-time PCR. P. multocida pneumonia increased Bax, Caspase-3, Atg5, Beclin-1, and RIP3 gene expressions (4.2, 3.8, 2.9, 2.1, 2.8-fold, respectively), whereas Bcl-2 gene expression was decreased (0.22-fold). While Bax, Caspase-3, Atg5, Beclin-1, and RIP3 gene expressions were increased in M. haemolytica pneumonia (2.3, 1.9, 1.7, 1.2, 4.2-fold, respectively), it was observed that Bcl-2 gene expression was reduced (0.52-fold). The results obtained in the study revealed the importance of necroptosis, apoptosis and autophagy processes in the pathogenesis of PP caused by P. multocida and M. haemolytica and contributed to the literature. In addition, we found that the processes of apoptosis and autophagy play a more active role in PP caused by P. multocida, and the process of necroptosis plays a more active role in PP caused by M. haemolytica.
Yazarlar (4)
1
G. Akcakavak
2
Ozhan Karatas
3
Nevin Tuzcu
ORCID: 0000-0001-5899-3955
4
Mehmet Tuzcu
Anahtar Kelimeler
Apoptosis
Autophagy
M. haemolytica
Necroptosis
P. multocida
Pneumonic pasteurellosis
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pakistan Veterinary Journal
Q1
OA
SJR Skoru0,717
H-Index40
YayıncıFaculty Of Veterinary Science, University Of Agriculture
ÜlkePakistan
Veterinary (miscellaneous) (Q1)
Metrikler
9
Atıf
4
Yazar
6
Anahtar Kelime