Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The prevalence of homozygous mthfr polymorphism(S) in a turkish university hospital population that necessitated mthfr polymorphism investigation
Electronic Journal of General Medicine · Ocak 2018
YÖKSİS Kayıtları
The prevalence of homozygous MTHFR polymorphism(s) in a Turkish university hospital population that necessitated MTHFR polymorphism investigation
Electronic Journal of General Medicine · 2018 Emerging Sources Citation Index
PROFESÖR GÖKÇEN ÖRGÜL →
Makale Bilgileri
DergiElectronic Journal of General Medicine
Yayın TarihiOcak 2018
Cilt / Sayfa15
Scopus ID2-s2.0-85055022653
Erişim🔓 Açık Erişim
Özet
Background: Methylenetetrahydrofolate reductase (MTHFR) polymorphisms may cause various medical disorders through different mechanisms. We aimed to determine the allelic frequency and the prevalence of homozygous MTHFR polymorphisms in a tertiary university hospital population that necessitated MTHFR polymorphism investigation owing to various reasons. Methods: Our study consisted of 10449 patients who necessitated MTHFR polymorphism investigation owing to various reasons (coronary artery diseases, thrombotic events, epilepsy, migraine, repeated miscarriages, various obstetric complications) during 2008-2017. Results: The allelic frequency of MTHFR 677 and MTHFR 1298 mutations were 0.296 and 0.283 respectively. The prevalence of homozygous MTHFR C677T and MTHFR A1298C polymorphisms were 10.2 % and 11.1 %, respectively. Conclusion: MTHFR polymorphisms are more frequent than was expected and one should be cautious when drawing disorder specific conclusions.
Yazarlar (6)
1
Fatma Gumruk
2
Gökçen Örgül
ORCID: 0000-0003-0578-4230
3
Ozlem Akgun Dogan
4
Atakan Tanacan
ORCID: 0000-0001-8209-8248
5
Ahmet Ergun Karaaǧaoǧlu
6
Mehmet Sinan Beksaç
ORCID: 0000-0001-6362-787X
Anahtar Kelimeler
Demographic analysis
Gene frequency
Genetic polymorphism
Methylenetetrahydrofolate reductase
Turkey
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Metrikler
7
Atıf
6
Yazar
5
Anahtar Kelime