Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus
Fetal and Pediatric Pathology · Ocak 2019
YÖKSİS Kayıtları
Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus
Fetal and Pediatric Pathology · 2019 SCI-Expanded
Prof. Dr. GÖKÇEN ÖRGÜL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The Effect of the 50 g Glucose Challenge Test on The Thiol/Disulfide Homeostasis in Pregnancy
2018 ISSN: 1551-3815 SCI
Prof. Dr. MEHMET KULHAN →
Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus
2019 ISSN: 1551-3815 SCI-Expanded
Prof. Dr. GÖKÇEN ÖRGÜL →
Maternal Serum and Umbilical Cord Brain Natriuretic Peptide Levels in Fetuses with Intrauterine Growth Restriction
2022 ISSN: 1551-3815 SCI-Expanded Q4
Prof. Dr. GÖKÇEN ÖRGÜL →
Makale Bilgileri
ISSN15513815
Yayın TarihiOcak 2019
Cilt / Sayfa38 · 376-386
Scopus ID2-s2.0-85063954211
Özet
Objective: To evaluate the impact of type-1 diabetes mellitus (DM) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms on impaired placentation leading to early pregnancy loss. Methods: Miscarriage materials were obtained from eight pregnant women with type-1 DM without MTHFR polymorphism, eight with MTHFR polymorphisms without type-1 DM, and eight controls with neither DM nor MTHFR polymorphisms. Insulin-like growth factor-1 (IGF-1), leukemia inhibitory factor (LIF), and Beclin-1 expression were assessed to evaluate placentation. Results: Cytoplasmic LIF, IGF-1, and Beclin-1 expression were decreased in the superficial and glandular epithelial cells of the decidua in both study groups. LIF expression was increased in interstitial trophoblasts in the MTHFR group. IGF-1 expression was decreased in the decidual cells and interstitial trophoblasts in both study groups, while the decrease in stromal cells was noted only in type-1 DM group. Beclin-1 expression was increased in interstitial and villous trophoblasts in both study groups. Conclusion: The expression of IGF-1, LIF, and Beclin-1 are altered in both the decidua and the trophoblasts in pregnancies of women with type-1 DM and MTHFR polymorphisms, compared to normal pregnancies undergoing (elective) terminations.
Yazarlar (7)
1
Rumeysa Hekimoglu Gurbuz
ORCID: 0000-0003-4300-7213
2
Pergin Atilla
ORCID: 0000-0001-5132-0002
3
Gökçen Örgül
ORCID: 0000-0003-0578-4230
4
Atakan Tanacan
ORCID: 0000-0001-8209-8248
5
Anil Dolgun
ORCID: 0000-0002-2693-0666
6
Ayse Nur Cakar
ORCID: 0000-0002-2585-7727
7
Mehmet Sinan Beksaç
ORCID: 0000-0001-6362-787X
Anahtar Kelimeler
beclin 1 protein
insulin like growth factor 1
leukemia inhibitory factor
MTHFR gene polymorphisms
type 1 diabetes mellitus
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
RMIT University
Melbourne Australia
TOBB University of Economics and Technology
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Fetal and Pediatric Pathology
Q3
SJR Skoru0,364
H-Index43
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q3)
Pathology and Forensic Medicine (Q3)
Pediatrics, Perinatology and Child Health (Q3)
Metrikler
17
Atıf
7
Yazar
5
Anahtar Kelime