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Myasthenia gravis and pregnancy: retrospective evaluation of 27 pregnancies in a tertiary center and comparison with previous studies

Irish Journal of Medical Science · Kasım 2019

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YÖKSİS Kayıtları
Myasthenia gravis and pregnancy: retrospective evaluation of 27 pregnancies in a tertiary center and comparison with previous studies
Irish Journal of Medical Science (1971 -) · 2019 SCI-Expanded
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Makale Bilgileri

DergiIrish Journal of Medical Science
Yayın TarihiKasım 2019
Cilt / Sayfa188 · 1261-1267
DOI10.1007/s11845-019-02029-0
Scopus ID2-s2.0-85065727762
Özet Background and aim: To share our experience with the management of pregnancies in women with myasthenia gravis (MG) in a tertiary center. Methods: The study retrospectively evaluated 27 pregnancies in 12 patients. The pregnancies were divided into 3 groups on the basis of the clinical course of MG during pregnancy: improvement (n = 7), disease-stable (n = 9), and deterioration (n = 11). The groups were compared with respect to patient characteristics, clinical features, and obstetric outcomes. Results: There were 4 miscarriages (14.8%), 3 preterm births (11.1%), and 4 cases of preterm premature rupture of the membranes (PPROM) (14.8%). Exacerbation was observed in 25.9% of the cases; the remission rate during the postpartum period and after miscarriage was 37%. The cesarean section (CS) rate was 78.3%. Pregnancies with deterioration of MG were statistically more likely to have higher miscarriage, preterm birth, PPROM, CS, and transient neonatal MG rates, in addition to a lower gestational age at birth, birth weight, and 5-min Apgar score than pregnancies with improved or stable disease (p values < 0.001, 0.04, 0.03, 0.009, 0.02, < 0.001, 0.002, and 0.043, respectively). Conclusion: Physicians who manage pregnant women with MG must be familiar with the clinical features of the condition; a multidisciplinary approach is necessary for a better prognosis.

Yazarlar (6)

1
Atakan Tanacan
ORCID: 0000-0001-8209-8248
2
Erdem Fadiloglu
3
Gonca Ozten
4
Ali Can Gunes
5
Gökçen Örgül
ORCID: 0000-0003-0578-4230
6
Mehmet Sinan Beksaç
ORCID: 0000-0001-6362-787X

Anahtar Kelimeler

Acetylcholine receptors Myasthenia gravis Neuromuscular junction Obstetric complications Pregnancy

Kurumlar

Hacettepe Üniversitesi
Ankara Turkey

Metrikler

23
Atıf
6
Yazar
5
Anahtar Kelime

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