Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Metabolic infrastructure of pregnant women with methylenetetrahydrofolate reductase polymorphisms: A metabolomic analysis
Biomedical Chromatography · Ağustos 2020
YÖKSİS Kayıtları
Metabolic infrastructure of pregnant women with methylenetetrahydrofolate reductase polymorphisms: A metabolomic analysis
BIOMEDICAL CHROMATOGRAPHY · 2020 SCI-Expanded
Prof. Dr. GÖKÇEN ÖRGÜL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Method Validation for the Determination of Nicotine and Nicotine Metabolite Levels in Urine, Serum and Saliva Samples
2025 ISSN: 0269-3879 SCI-Expanded Q3
Prof. Dr. FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Metabolic infrastructure of pregnant women with methylenetetrahydrofolate reductase polymorphisms: A metabolomic analysis
2020 ISSN: 0269-3879 SCI-Expanded
Prof. Dr. GÖKÇEN ÖRGÜL →
New steps in acute coronary syndrome and antihyperlipidemic treatment: Determination of statins and metabolites by liquid chromatography tandem mass spectrometry
2022 ISSN: 0269-3879 SCI-Expanded Q3
Prof. Dr. ALİ ÜNLÜ →
New steps in acute coronary syndrome and antihyperlipidemic treatment: Determination of statins and metabolites by liquid chromatography tandem mass spectrometry
2022 ISSN: 0269-3879 SCI-Expanded Q4
Doç. Dr. GÜLSÜM ABUŞOĞLU →
New steps in acute coronary syndrome and antihyperlipidemic treatment: Determination of statins and metabolites by liquid chromatography tandem mass spectrometry
2022 ISSN: 0269-3879 EBSCO, İndex Copernicus
Prof. Dr. ALİ ÜNLÜ →
New steps in acute coronary syndrome and antihyperlipidemic treatment: Determination of statins and metabolites by liquid chromatography tandem mass spectrometry
2022 ISSN: 0269-3879 SCI-Expanded Q4
Doç. Dr. KENAN ERDEM →
Method Validation for the Determination of Nicotine and Nicotine Metabolite Levels in Urine, Serum, and Saliva Samples
2025 ISSN: 0269-3879 SCI-Expanded Q3
Prof. Dr. ALİ ÜNLÜ →
Makale Bilgileri
ISSN02693879
Yayın TarihiAğustos 2020
Cilt / Sayfa34
Scopus ID2-s2.0-85083671105
Özet
The aim of this study was to demonstrate the altered metabolic infrastructure of pregnant women with methylenetetrahydrofolate reductase (MTHFR) polymorphisms at first trimester and during delivery. Eight singleton pregnant women with MTHFR polymorphisms were compared with 10 normal pregnant women. Maternal blood samples were obtained twice during their pregnancy period (between the 11th and 14th gestational weeks and during delivery). Metabolomic analysis was performed using GC–MS. The GC–MS based metabolomic profile helped identify 95 metabolites in the plasma samples. In the MTHFR group, the levels of 1-monohexadecanoylglycerol, pyrophosphate, benzoin, and linoleic acid significantly decreased (P ˂ 0.05 for all), whereas the levels of glyceric acid, l-tryptophan, l-alanine, l-proline, norvaline, l-threonine, and myo-inositol significantly increased (P ˂ 0.01 for the first two metabolites, P ˂ 0.05 for the others) at 11–14 gestational weeks. Conversely, the levels of benzoin, 1-monohexadecanoylglycerol, pyruvic acid, l-proline, phosphoric acid, epsilon-caprolactam, and pipecolic acid significantly decreased in the MTHFR group, whereas metabolites such as hexadecanoic acid and 2-hydroxybutyric acid increased significantly in the study group during delivery. An impaired energy metabolism pathway, vitamin B complex disorders, tendency for metabolic acidosis (oxidative stress), and the need for cell/tissue support seem prevalent in pregnancies with MTHFR polymorphisms.
Yazarlar (7)
1
Tuba Recber
ORCID: 0000-0001-8257-7628
2
Gökçen Örgül
ORCID: 0000-0003-0578-4230
3
Emine Aydın
ORCID: 0000-0001-8877-2803
4
Atakan Tanacan
ORCID: 0000-0001-8209-8248
5
Emirhan Nemutlu
ORCID: 0000-0002-7337-6215
6
Sedef Kır
ORCID: 0000-0003-1322-1665
7
Mehmet Sinan Beksaç
ORCID: 0000-0001-6362-787X
Anahtar Kelimeler
GC–MS, metabolomics, methylenetetrahydrofolate reductase polymorphisms, pregnancy
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Biomedical Chromatography
Q3
SJR Skoru0,368
H-Index76
YayıncıJohn Wiley and Sons Ltd
ÜlkeUnited Kingdom
Analytical Chemistry (Q3)
Biochemistry (Q3)
Clinical Biochemistry (Q3)
Drug Discovery (Q3)
Medicine (miscellaneous) (Q3)
Pharmacology (Q3)
Molecular Biology (Q4)
Metrikler
8
Atıf
7
Yazar
1
Anahtar Kelime