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Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?

Zeitschrift fur Geburtshilfe und Neonatologie · Nisan 2021

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Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?
Zeitschrift für Geburtshilfe und Neonatologie · 2021 SCI-Expanded
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Makale Bilgileri

DergiZeitschrift fur Geburtshilfe und Neonatologie
Yayın TarihiNisan 2021
Cilt / Sayfa225 · 125-128
DOI10.1055/a-1382-8787
Scopus ID2-s2.0-85102510337
Özet Purpose To evaluate the usability of first-trimester maternal serum ProBNP levels in the prediction of intrauterine growth restriction (IUGR). Methods In this prospective study, blood samples taken from 500 women who applied to our polyclinic for routine serum aneuploidy screening between the 11-14th gestational weeks were centrifuged. The obtained plasma samples were placed in Eppendorf tubes and stored at -80+°C. For the final analysis, first-trimester maternal serum ProBNP levels of 32 women diagnosed with postpartum IUGR and 32 healthy women randomly selected as the control group were compared. FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Results The mean ProBNP levels were statistically and significantly higher in the women with intrauterine growth restriction (113.73±94.69 vs. 58.33±47.70 pg/mL, p<0.01). At a cut-off level of 50.93, ProBNP accurately predicted occurrence of IUGR (AUC+= 0.794 (95% confidence interval 0.679-0.910), p+= 0.001) with sensitivity and specificity rates of 78.1 and 69.0%, respectively. Conclusion First-trimester serum ProBNP level was significantly higher in women who developed IUGR compared to healthy controls. First-trimester ProBNP level can be used as a potential marker to predict the development of IUGR in pregnant women.

Yazarlar (7)

1
Hasan Eroğlu
ORCID: 0000-0002-1180-5299
2
Nazan Vanll Tonyall
3
Gökçen Örgül
ORCID: 0000-0003-0578-4230
4
Derya Biriken
ORCID: 0000-0002-6254-4578
5
Aykan Yücel
6
Nuray Yazihan
ORCID: 0000-0003-1237-8468
7
Dilek Uygur

Anahtar Kelimeler

first trimester intrauterine growth restriction placenta Pregnancy ProBNP

Kurumlar

Ankara Üniversitesi
Ankara Turkey
Etlik Zubeyde Hanim Women's Health Education and Research Hospital
Ankara Turkey

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