Scopus
YÖKSİS Eşleşti
Significance of inhibitory maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotype combinations in placenta related obstetric complications
Journal of Reproductive Immunology · Kasım 2021
YÖKSİS Kayıtları
Significance of inhibitory maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotype combinations in placenta related obstetric complications
Journal of Reproductive Immunology · 2021 SCI
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Makale Bilgileri
DergiJournal of Reproductive Immunology
Yayın TarihiKasım 2021
Cilt / Sayfa148
Scopus ID2-s2.0-85116039673
Özet
Some maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotypes are associated with obstetric complications, such as recurrent miscarriage, fetal growth restriction, preeclampsia, and preterm birth. However, how KIR/KIR ligand genotypes affect these placenta-related obstetric complications has not been fully understood. We aimed to demonstrate the association of maternal KIR-fetal KIR ligand genotype combinations with immunological/metabolic risk factor associated placenta-related obstetric complications. This study consisted of three groups of pregnant women: 1) Miscarriage group (n = 30), 2) Complicated Pregnancy (CP) group (n = 30), and 3) Control group (n = 30). The observed maternal genotype frequencies of all inhibitory and activating KIRs were similar in all groups (p > 0.05). However, inhibitory 2DL3 was quite frequent in the miscarriage group (p = 0.052). There was no difference between groups in terms of centromeric and telomeric maternal haplotypes (p > 0.05). The fetal group 1 HLA-C genotype was frequently detected in the miscarriage and CP groups with rates of 83.3 % and 93.3 % respectively, while the observed frequency was 70 % in the control group. The fetal group 2 HLA-C genotype was the same in all groups. The results demonstrated significantly less fetal group 2 HLA-C homozygosity in the CP groups when compared to the control group (p = 0.020). The fetal HLA-Bw4 genotype was detected more frequently in the miscarriage and CP groups (p = 0.028 and p = 0.001, respectively). The inhibitory KIR/KIR ligand genotype combinations of 2DL3-C1 and 3DL1-Bw4 were more frequent in the miscarriage and CP groups (p = 0.045 and p = 0.002, respectively). Enhanced NK cell inhibition may be one of the mechanisms underlying placenta-related obstetric complications.
Yazarlar (8)
1
Gökçen Örgül
ORCID: 0000-0003-0578-4230
2
Klara Dalva
ORCID: 0000-0001-6917-6870
3
Sevim Dalva-Aydemir
ORCID: 0000-0001-8957-9597
4
Ridvan Goksel Alniacik
ORCID: 0000-0002-3871-8603
5
Hanife Guler Donmez
ORCID: 0000-0002-7413-4939
6
Ayse Nur Cakar
ORCID: 0000-0002-2585-7727
7
Meral Beksac
ORCID: 0000-0003-1797-8657
8
Mehmet Sinan Beksaç
ORCID: 0000-0001-6362-787X
Anahtar Kelimeler
Killer cell immunoglobulin like receptor
Major histocompatibility complex Class-I antigen
Miscarriage
Natural killer cell
Obstetric complication
Placental inflammation
Pregnancy
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
TOBB University of Economics and Technology
Ankara Turkey
Metrikler
3
Atıf
8
Yazar
7
Anahtar Kelime