Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Does Second Trimester Maternal Serum Zonulin Level Predict Gestational Diabetes Mellitus?
Journal of Clinical Medicine · Ocak 2024
YÖKSİS Kayıtları
Does Second Trimester Maternal Serum Zonulin Level Predict Gestational Diabetes Mellitus?
Journal of Clinical Medicine · 2024 SCI-Expanded
PROFESÖR GÖKÇEN ÖRGÜL →
Makale Bilgileri
DergiJournal of Clinical Medicine
Yayın TarihiOcak 2024
Cilt / Sayfa13
Scopus ID2-s2.0-85183436079
Erişim🔓 Açık Erişim
Özet
Zonulin, a protein that regulates intestinal permeability, has attracted attention as a potential biomarker for GDM. Therefore, this study aims to investigate whether there are differences in zonulin levels between the GDM group and control groups, especially between those receiving different treatments (diet and insulin). Based on this idea, we included 90 patients with a gestational age between 24 and 28 weeks in our study. While GDM was not detected in 33 of these patients, as a result of OGTT, 57 patients were diagnosed with GDM and these patients were followed throughout their pregnancy. Gestational diabetes was diagnosed by an OGTT performed between 24 and 28 weeks of gestation according to American Diabetes Association (ADA) standards. During follow-up, GDM patients were divided into two groups according to whether they required insulin treatment. Plasma zonulin levels were determined using enzyme-linked immunosorbent assay (ELISA) techniques. The GDM group had significantly higher plasma zonulin levels than the control group (p < 0.005). According to our research, zonulin may be a non-invasive biomarker involved in the etiology of GDM. Large-scale research on this topic is still needed.
Yazarlar (9)
1
Nazan Vanlı Tonyalı
ORCID: 0000-0002-7284-6887
2
Burak Arslan
3
Serap Topkara Sucu
4
Kemal Sarsmaz
ORCID: 0000-0003-0028-3576
5
Müjde Can İbanoğlu
ORCID: 0000-0002-8413-2064
6
Gökçen Örgül
ORCID: 0000-0003-0578-4230
7
Gizem Aktemur
8
Aykan Yücel
9
Dilek Şahin
ORCID: 0000-0001-8567-9048
Anahtar Kelimeler
gestational diabetes mellitus
gestational diabetes mellitus therapy
zonulin
Kurumlar
Etlik Zubeyde Hanim Women's Health Training and Research Hospital
Ankara Turkey
Manisa Celâl Bayar Üniversitesi
Manisa Turkey
Sahlgrenska Akademin
Gothenburg Sweden
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
1
Atıf
9
Yazar
3
Anahtar Kelime