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Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds

Journal of Drug Delivery Science and Technology · Ekim 2017

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YÖKSİS Kayıtları
Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
Journal of Drug Delivery Science and Technology · 2017 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 16 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
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Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
2017 ISSN: 1773-2247 SSCI
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Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein
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Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
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Preparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinning
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Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
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Prof. Dr. ABDULLAH SİVRİKAYA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
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Arş. Gör. KÜBRA YILMAZ →
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2024 ISSN: 1773-2247 SCI-Expanded Q1
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Makale Bilgileri

ISSN17732247
Yayın TarihiEkim 2017
Cilt / Sayfa41 · 280-292
Özet The objective of the present investigation was to develop novel three-dimensional (3D) and biodegradable tissue scaffolds (TSs), consisting of biological polymers and simvastatin (SV)-loaded nanostructured lipid carriers (NLCs) for the treatment of diabetic wounds. NLCs were prepared via high-shear homogenization and freeze-drying was used for NLC-incorporated TSs. The resulting NLC suspension contained spherical nanosized (110–158 nm) homogeneous particles (PDI<0.16) with >99% encapsulation efficiency. The NLCs were characterized via differential scanning calorimetry and Fourier transform infrared spectroscopy analysis. TSs have 3D high porous structure (74.38%) and sufficient large pore size (∼100–200 μm), low weight loss (57.7%), high absorption capacity (710.88%) and good mechanical strength. Incorporation of NLCs into TSs delayed the initial SV release and generated a more controlled release profile. Biocompatibility of the TSs was shown using MTT assay. The results suggest that TSs can be considered as suitable candidates for diabetic wound treatment.

Yazarlar (3)

1
Dilara Orgul
2
Hakan Eroğlu
3
Sueda Hekimoglu

Anahtar Kelimeler

Diabetic wound Nanostructured lipid carrier NLC Simvastatin Tissue scaffold Wound healing

Kurumlar

Hacettepe Üniversitesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Drug Delivery Science and Technology
Q2
SJR Skoru0,780
H-Index102
YayıncıEditions de Sante
ÜlkeFrance
Pharmaceutical Science (Q2)
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Metrikler

20
Atıf
3
Yazar
6
Anahtar Kelime