Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
Journal of Drug Delivery Science and Technology · Ekim 2017
YÖKSİS Kayıtları
Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
Journal of Drug Delivery Science and Technology · 2017 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme
2020 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi SEMA ARISOY →
In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
2021 ISSN: 1773-2247 SSCI Q2
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
2017 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein
2019 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Development and characterization of polymeric nanoparticles containing ondansetron hydrochloride as a hydrophilic drug
2022 ISSN: 1773-2247 SCI-Expanded Q2
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Arş. Gör. TAMER TEKİN →
Preparation, characterization and evaluation of liposomal-freeze dried anthocyanin-enriched Vaccinium arctostaphylos L. fruit extract incorporated into fast dissolving oral films
2022 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. YÜKSEL KAN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ZELİHA ESİN ÇELİK →
Preparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinning
2024 ISSN: 1773-2247 SCI Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation
2024 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. MEHMET TUZCU →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Arş. Gör. KÜBRA YILMAZ →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi HARUN YONAR →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Öğr. Gör. FATİH ÖZCAN →
Development of phytase targeted PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and evaluation of efficacy on the hydatid cysts
2025 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Makale Bilgileri
ISSN17732247
Yayın TarihiEkim 2017
Cilt / Sayfa41 · 280-292
Scopus ID2-s2.0-85026893575
Özet
The objective of the present investigation was to develop novel three-dimensional (3D) and biodegradable tissue scaffolds (TSs), consisting of biological polymers and simvastatin (SV)-loaded nanostructured lipid carriers (NLCs) for the treatment of diabetic wounds. NLCs were prepared via high-shear homogenization and freeze-drying was used for NLC-incorporated TSs. The resulting NLC suspension contained spherical nanosized (110–158 nm) homogeneous particles (PDI<0.16) with >99% encapsulation efficiency. The NLCs were characterized via differential scanning calorimetry and Fourier transform infrared spectroscopy analysis. TSs have 3D high porous structure (74.38%) and sufficient large pore size (∼100–200 μm), low weight loss (57.7%), high absorption capacity (710.88%) and good mechanical strength. Incorporation of NLCs into TSs delayed the initial SV release and generated a more controlled release profile. Biocompatibility of the TSs was shown using MTT assay. The results suggest that TSs can be considered as suitable candidates for diabetic wound treatment.
Yazarlar (3)
1
Dilara Orgul
2
Hakan Eroğlu
3
Sueda Hekimoglu
Anahtar Kelimeler
Diabetic wound
Nanostructured lipid carrier
NLC
Simvastatin
Tissue scaffold
Wound healing
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Drug Delivery Science and Technology
Q2
SJR Skoru0,780
H-Index102
YayıncıEditions de Sante
ÜlkeFrance
Pharmaceutical Science (Q2)
Metrikler
20
Atıf
3
Yazar
6
Anahtar Kelime