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Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein

Journal of Drug Delivery Science and Technology · Ağustos 2019

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YÖKSİS Kayıtları
Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein
Journal of Drug Delivery Science and Technology · 2019 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 16 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme
2020 ISSN: 1773-2247 SCI-Expanded
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In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
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Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
2017 ISSN: 1773-2247 SSCI
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Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein
2019 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Development and characterization of polymeric nanoparticles containing ondansetron hydrochloride as a hydrophilic drug
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Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
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Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
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Preparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinning
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Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation
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Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
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Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
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Prof. Dr. ABDULLAH SİVRİKAYA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
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Arş. Gör. KÜBRA YILMAZ →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi HARUN YONAR →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
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Development of phytase targeted PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and evaluation of efficacy on the hydatid cysts
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Makale Bilgileri

Dergi Journal of Drug Delivery Science and Technology
ISSN17732247
Yayın TarihiAğustos 2019
Cilt / Sayfa52 · 189-203
DOI10.1016/j.jddst.2019.04.027
Scopus ID2-s2.0-85064602341
Özet Daidzein (DZ) has antioxidant, anti-inflammatory activities and also inhibits the growth of the cancer cells. The aim of this study is to formulate nanoemulsions (NEs) and nanoemulsion-based gels (NEGs) containing DZ, in order to evaluate their cytotoxic potential for topical application against melanoma. The NE formulations were prepared by using a high-pressure homogenization technique. Protasan ™ UP G 213 (1% w/w) was added to the NE formulation to prepare NEG formulations. Droplet size values were 151.12 ± 2.70 nm and 149.80 ± 3.52 nm for Blank-NE (B-NE) and DZ-NE, 191.48 ± 5.26 nm and 200.25 ± 11.09 nm for B-NEG and DZ-NEG, respectively. Positive zeta potential values for the NEG formulations were obtained in the presence of Protasan ™ UP G 213. All formulations had appropriate pH values for skin and also complied with zero-order release kinetics. The DZ release rates obtained for DZ-NE and DZ-NEG were 2.701 ± 0.265 and 1.325 ± 0.117 μg/cm2/hour, respectively. During the stability study, NE and NEG formulations had droplet sizes in the nano-range. All formulations maintained the cytotoxic effect of DZ against the melanoma cell line. NE and NEG formulations with a controlled release profile and nanometer droplet size may be useful for the topical use of DZ and the treatment of skin cancer.

Yazarlar (6)

1
Afife Busra Ugur Kaplan
2
Meltem Cetin
3
Dilara Orgul
4
Ali Taghizadehghalehjoughi
5
Ahmet Hacımuftuoglu
6
Sueda Hekimoglu

Anahtar Kelimeler

Daidzein Nanoemulsion Nanoemulsion-based gel Skin cancer Stability

Kurumlar

Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Hacettepe Üniversitesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Drug Delivery Science and Technology
Q2
SJR Skoru0,780
H-Index102
YayıncıEditions de Sante
ÜlkeFrance
Pharmaceutical Science (Q2)
Dergi sayfasına git

Metrikler

89
Atıf
6
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

DÖ
DİLARA ÖRGÜL
Dr. Öğr. Üyesi

Hızlı Erişim

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