Scopus
YÖKSİS DOI Eşleşti
SJR Q1
In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
Journal of Drug Delivery Science and Technology · Şubat 2021
YÖKSİS Kayıtları
In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
Journal of Drug Delivery Science and Technology · 2021 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme
2020 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi SEMA ARISOY →
In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
2021 ISSN: 1773-2247 SSCI Q2
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
2017 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein
2019 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Development and characterization of polymeric nanoparticles containing ondansetron hydrochloride as a hydrophilic drug
2022 ISSN: 1773-2247 SCI-Expanded Q2
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Arş. Gör. TAMER TEKİN →
Preparation, characterization and evaluation of liposomal-freeze dried anthocyanin-enriched Vaccinium arctostaphylos L. fruit extract incorporated into fast dissolving oral films
2022 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. YÜKSEL KAN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ZELİHA ESİN ÇELİK →
Preparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinning
2024 ISSN: 1773-2247 SCI Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation
2024 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. MEHMET TUZCU →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Arş. Gör. KÜBRA YILMAZ →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi HARUN YONAR →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Öğr. Gör. FATİH ÖZCAN →
Development of phytase targeted PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and evaluation of efficacy on the hydatid cysts
2025 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Makale Bilgileri
ISSN17732247
Yayın TarihiŞubat 2021
Cilt / Sayfa61
Scopus ID2-s2.0-85092661134
Özet
Efficacy of simvastatin on wound healing and stem cell treatment, in addition to the cholesterol lowering mechanism, has been investigated in recent studies. In this study we have focused on formulation of tissue scaffolds comprised of mesenchymal stem cells and simvastatin loaded nanostructured lipid carriers (NLCs) dispersed in a polymeric matrix. These three dimensional and biodegradable systems were designed to bring a new perspective in treatment of diabetic wound. Therefore, NLC formulations containing simvastatin at the concentrations of 10% or 20% of lipid phase were prepared by high pressure homogenization technique. Simvastatin loaded NLC formulations were characterized with mean particle size of 158.15 ± 1.229 nm, PDI values lower than 0.17 and encapsulation efficiency above 99%. In-vitro release studies of simvastatin loaded NLC formulations were characterized by a high burst-release followed by sustained up to 12–24 h. Tissue scaffold formulations containing simvastatin loaded NLCs were prepared by freeze drying method. Cross-linked tissue scaffold formulations were prepared with 2:1 chitosan:collagen polymer ratio and 2-fold concentrated NLC formulation, having a three-dimensional structure with porosity value of 74.38%, pore size distribution within 20–200 μm, 710.88% high water absorption capacity, 57.7% weight loss and suitable mechanical strength for in-vivo studies. Incorporation of NLCs into tissue scaffolds decreased the initial simvastatin burst release ratio and provided controlled release profile. Tissue scaffolds containing simvastatin lipid nanoparticles increased wound closure rate, promoted vascularization of injured tissue and enhanced viability and proliferation of stem cells. Thereupon, tissue scaffold formulation containing simvastatin lipid nanoparticles and stem cells together provided effective wound healing with increased epithelialization, proliferation and vascularization.
Yazarlar (5)
1
Dilara Orgul
2
Hakan Eroğlu
3
Meral Tiryaki
4
Ferda Alpaslan Pınarlı
5
Sueda Hekimoglu
Anahtar Kelimeler
Nanostructured lipid carriers
Simvastatin
Stem cells
Tissue scaffold
Wound healing
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
T. C. Sağlık Bakanlığı Ankara Diskapi Yildirim Beyazit Eğitim ve Araştirma Hastanesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Drug Delivery Science and Technology
Q1
SJR Skoru0,817
H-Index89
YayıncıEditions de Sante
ÜlkeFrance
Pharmaceutical Science (Q1)
Metrikler
25
Atıf
5
Yazar
5
Anahtar Kelime